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Peptide record

TPDB11777

Pituitary adenylate cyclase-activating polypeptide Antibacterial Anticancer Antifungal Neuropeptide Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11777
Pituitary adenylate cyclase-activating polypeptide
Antibacterial Anticancer Antifungal Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Neuroactive peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGRRYRQRFRNK
Physicochemical Analysis
C207H330N68O54S1
CEPW
R
4667.38
11.40
12
2
15
+9
7.13
-1.145
53.95
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5960
127.69
11
Residue Composition
number
3
A
7
R
1
N
2
D
0
C
0
E
2
Q
2
G
1
H
1
I
2
L
4
K
1
M
2
F
0
P
3
S
1
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 3 R: 7 N: 1 D: 2 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 1 L: 2 K: 4 M: 1 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 4 V: 2
Chemical Descriptors
38
C207H330N68O54S1
4667.38
11.40
+9
7.13
-1.145
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Y. ruckeri

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against fish Gram- pathogens Y. ruckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

A. salmonicida

Source & Reference

dbAMP

Other

Active against fish Gram- pathogens Y. ruckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.h
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

t fish Gram- pathogens Y. ruckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC >
Evidence 4 Activity

Activity

MIC
Antibacterial
75 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

ckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 3
Evidence 5 Activity

Activity

MIC
Antibacterial
300 µM

Target

A.hydrophila

Source & Reference

dbAMP

Other

uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 300 uM), E.coli (MIC >300 uM), and Salmonella
Evidence 6 Activity

Activity

MIC
Antibacterial
300 µM

Target

P.aeruginosa

Source & Reference

dbAMP

Other

lbicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 300 uM), E.coli (MIC >300 uM), and Salmonella sp. (MIC 300 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>300 µM

Target

E.coli

Source & Reference

dbAMP

Other

ve against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 300 uM), E.coli (MIC >300 uM), and Salmonella sp. (MIC 300 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
50 µM

Target

Y. ruckeri

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against fish Gram- pathogens Y. ruckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC
Evidence 9 Activity

Activity

MIC
Antifungal
50 µM

Target

A. salmonicida

Source & Reference

dbAMP CAFPdb

Other

Active against fish Gram- pathogens Y. ruckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.h
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

B. subtilis

Source & Reference

dbAMP CAFPdb

Other

t fish Gram- pathogens Y. ruckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC >
Evidence 11 Activity

Activity

MIC
Antifungal
75 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb

Other

ckeri (MIC 50 uM), A. salmonicida (MIC 50 uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 3
Evidence 12 Activity

Activity

MIC
Antifungal
300 µM

Target

A.hydrophila

Source & Reference

dbAMP CAFPdb

Other

uM), human bacteria B. subtilis (MIC 5 uM), and C. albicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 300 uM), E.coli (MIC >300 uM), and Salmonella
Evidence 13 Activity

Activity

MIC
Antifungal
300 µM

Target

P.aeruginosa

Source & Reference

dbAMP CAFPdb

Other

lbicans (MIC 75 uM). Inactive against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 300 uM), E.coli (MIC >300 uM), and Salmonella sp. (MIC 300 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
>300 µM

Target

E.coli

Source & Reference

dbAMP CAFPdb

Other

ve against A.hydrophila (MIC 300 uM), S.aureus (MIC > 300 uM), P.aeruginosa (MIC 300 uM), E.coli (MIC >300 uM), and Salmonella sp. (MIC 300 uM).
Evidence 15 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Clarias macrocephalus
Glucagon
Evidence 16 Activity

Activity

0% Hemolysis
Toxicity
<75 µM
Hemolytic Cytotoxic
0% Hemolysis | <75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. | Fish Shellfish Immunol | 2018
Evidence 17 Activity

Activity

<3% Hemolysis
Toxicity
75-150 µM
Hemolytic Cytotoxic
<3% Hemolysis | 75-150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. | Fish Shellfish Immunol | 2018
Evidence 18 Activity

Activity

6% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
6% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. | Fish Shellfish Immunol | 2018
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
<18.75 µM
Hemolytic Cytotoxic
0% Hemolysis | <18.75 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. | Fish Shellfish Immunol | 2018
Evidence 20 Activity

Activity

<20% Hemolysis
Toxicity
18.75-150 µM
Hemolytic Cytotoxic
<20% Hemolysis | 18.75-150 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. | Fish Shellfish Immunol | 2018
Evidence 21 Activity

Activity

39% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
39% Hemolysis | 300 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. | Fish Shellfish Immunol | 2018
Evidence 22 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells: PACAP was not hemolytic for human erythrocytes at concentrations below 75 µM (0% hemolysis). At concentration between 75 µM and 150 µM the hemolytic activity was less than 3% Fish red blood cells:PACAP was not hemolytic for fish red blood cells at concentrations below 18.75 µM (0% hemolysis). At concentration between 18.75 µM and 150 µM, the hemolytic activity was less than 20% | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Fish Shellfish Immunol. 2019 Mar 86:559-570.
Additional Detail Fields 1 fields
Glucagon