Back to search

Peptide record

TPDB11776

Antibacterial Antifungal Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11776
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GFGCPLNERECHSHCQSIGRKFGYCGGTLRLTCICGKE
Physicochemical Analysis
C174H275N55O52S6
ADMWV
G
4161.79
8.02
7
3
8
+2
7.51
-0.339
51.32
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
44.81
13
Residue Composition
number
0
A
3
R
1
N
0
D
6
C
3
E
1
Q
7
G
2
H
2
I
3
L
2
K
0
M
2
F
1
P
2
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 6 E: 3 Q: 1 G: 7 H: 2 I: 2 L: 3 K: 2 M: 0 F: 2 P: 1 S: 2 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
38
C174H275N55O52S6
4161.79
8.02
+2
7.51
-0.339
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.06-0.25 µM

Target

Staphylococcus aureus AB94004 or ATCC25923 or ATCC6538

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus AB94004 or ATCC25923 or ATCC6538 (MIC 0.06-0.25 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. su
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Staphylococcus epidermidis AB208187 or AB208188

Source & Reference

dbAMP

Other

Active against S. aureus AB94004 or ATCC25923 or ATCC6538 (MIC 0.06-0.25 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E.
Evidence 3 Activity

Activity

MIC
Antibacterial
0.06 µM

Target

M. luteus AB93113

Source & Reference

dbAMP

Other

CC25923 or ATCC6538 (MIC 0.06-0.25 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.
Evidence 4 Activity

Activity

MIC
Antibacterial
0.25 µM

Target

B. subtilis AB91021

Source & Reference

dbAMP

Other

5 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027
Evidence 5 Activity

Activity

MIC
Antibacterial
0.06-0.25 µM

Target

Escherichia coli AB94012 or ATCC25922

Source & Reference

dbAMP

Other

uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 u
Evidence 6 Activity

Activity

MIC
Antibacterial
0.06-0.25 µM

Target

Pseudomonas aeruginosa ATCC9027 or ATCC27853

Source & Reference

dbAMP

Other

AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis
Evidence 7 Activity

Activity

MIC
Antibacterial
0.25 µM

Target

Klebsiella pneumoniae RM3017

Source & Reference

dbAMP

Other

or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis RM1003 (MIC 16 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans RM2018

Source & Reference

dbAMP

Other

aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis RM1003 (MIC 16 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
16 µM

Target

C. parapsilosis RM1003

Source & Reference

dbAMP

Other

IC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis RM1003 (MIC 16 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
0.06-0.25 µM

Target

Staphylococcus aureus AB94004 or ATCC25923 or ATCC6538

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus AB94004 or ATCC25923 or ATCC6538 (MIC 0.06-0.25 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. su
Evidence 11 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Staphylococcus epidermidis AB208187 or AB208188

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus AB94004 or ATCC25923 or ATCC6538 (MIC 0.06-0.25 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E.
Evidence 12 Activity

Activity

MIC
Antifungal
0.06 µM

Target

M. luteus AB93113

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CC25923 or ATCC6538 (MIC 0.06-0.25 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.
Evidence 13 Activity

Activity

MIC
Antifungal
0.25 µM

Target

B. subtilis AB91021

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5 uM), S. epidermidis AB208187 or AB208188 (MIC 4-8 uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027
Evidence 14 Activity

Activity

MIC
Antifungal
0.06-0.25 µM

Target

Escherichia coli AB94012 or ATCC25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), M. luteus AB93113 (MIC 0.06 uM), B. subtilis AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 u
Evidence 15 Activity

Activity

MIC
Antifungal
0.06-0.25 µM

Target

Pseudomonas aeruginosa ATCC9027 or ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

AB91021 (MIC 0.25 uM), MRSA (32 uM), G- E. coli AB94012 or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis
Evidence 16 Activity

Activity

MIC
Antifungal
0.25 µM

Target

Klebsiella pneumoniae RM3017

Source & Reference

dbAMP CAFPdb Antifungipept

Other

or ATCC25922 (MIC 0.06-0.25 uM), P. aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis RM1003 (MIC 16 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
16 µM

Target

Candida albicans RM2018

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aeruginosa ATCC9027 or ATCC27853 (MIC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis RM1003 (MIC 16 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
16 µM

Target

C. parapsilosis RM1003

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 0.06-0.25 uM), K. pneumoniae RM3017 (MIC 0.25 uM), C. albicans RM2018 (MIC 16 uM), and C. parapsilosis RM1003 (MIC 16 uM).
Evidence 19 Activity

Activity

1.1% Hemolysis
Toxicity
32.25 µg/mL
Hemolytic Cytotoxic
1.1% Hemolysis | 32.25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity. | Peptides | 2018
Evidence 20 Activity

Activity

3.2% Hemolysis
Toxicity
62.6 µg/mL
Hemolytic Cytotoxic
3.2% Hemolysis | 62.6 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity. | Peptides | 2018
Evidence 21 Activity

Activity

5.4% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
5.4% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity. | Peptides | 2018
Evidence 22 Activity

Activity

7.9% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
7.9% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity. | Peptides | 2018
Evidence 23 Activity

Activity

14.1% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
14.1% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity. | Peptides | 2018
Evidence 24 Activity

Activity

23.5% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
23.5% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity. | Peptides | 2018