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Peptide record

TPDB11774

Antibacterial Hemolysis Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB11774
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
AQWFAIQHISLNPPRSTIAMRAINNYRWRSKNQNTFLR
Physicochemical Analysis
C206H320N66O53S1
DCEGV
RN
4601.28
12.58
7
0
16
+6
1.24
-0.721
72.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
271.45
14
Residue Composition
number
4
A
5
R
5
N
0
D
0
C
0
E
3
Q
0
G
1
H
4
I
2
L
1
K
1
M
2
F
2
P
3
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 5 N: 5 D: 0 C: 0 E: 0 Q: 3 G: 0 H: 1 I: 4 L: 2 K: 1 M: 1 F: 2 P: 2 S: 3 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
38
C206H320N66O53S1
4601.28
12.58
+6
1.24
-0.721
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
10.5±0.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 10.5±0.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. | J Med Chem | 2011
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis