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Peptide record

TPDB11773

Antibacterial Antifungal standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11773
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 38-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
WQQPSCSSICDYSCGKSACISYSGRCGCCASCRRGPIY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C166H257N51O54S8
NEHLMFTV
CS
4087.66
8.09
4
1
9
+3
1.66
-0.179
36.05
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
10470
2.56
21
Residue Composition
number
2
A
3
R
0
N
1
D
8
C
0
E
2
Q
4
G
0
H
3
I
0
L
1
K
0
M
0
F
2
P
8
S
0
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 1 C: 8 E: 0 Q: 2 G: 4 H: 0 I: 3 L: 0 K: 1 M: 0 F: 0 P: 2 S: 8 T: 0 W: 1 Y: 3 V: 0
Chemical Descriptors
38 reviewed residue count
C166H257N51O54S8 sequence-only estimate (linear, free termini)
4087.66 sequence-only estimate (linear, free termini)
8.09 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
1.66 sequence-only estimate (linear, free termini)
-0.179 sequence-only estimate (linear, free termini)
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli

Source & Reference

NA

Other

inst marine bacteria, but very weakly in vitro. Activity tested against Gram- terrestrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.aeruginosa

Source & Reference

NA

Other

but very weakly in vitro. Activity tested against Gram- terrestrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µM

Target

Y.ruckeri

Source & Reference

NA

Other

tested against Gram- terrestrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum
Evidence 4 Activity

Activity

MIC
Antibacterial
>100 µM

Target

L.anguillarum

Source & Reference

NA

Other

estrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >1
Evidence 5 Activity

Activity

MIC
Antibacterial
200 µM

Target

A.salmonicida

Source & Reference

NA

Other

P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µM

Target

C.glutamicum

Source & Reference

NA

Other

(MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.diverge
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.aureus

Source & Reference

NA

Other

um (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.f
Evidence 8 Activity

Activity

MIC
Antibacterial
200 µM

Target

C.maltaromaticum

Source & Reference

NA

Other

onicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remain
Evidence 9 Activity

Activity

MIC
Antibacterial
100 µM

Target

C. mobile

Source & Reference

NA

Other

restrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remains to be tested whether t
Evidence 10 Activity

Activity

MIC
Antibacterial
200 µM

Target

C.divergens

Source & Reference

NA

Other

IC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remains to be tested whether the peptide is more active
Evidence 11 Activity

Activity

MIC
Antibacterial
200 µM

Target

C.funditum

Source & Reference

NA

Other

uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remains to be tested whether the peptide is more active at low temperature where the
Evidence 12 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli

Source & Reference

Antifungipept

Other

inst marine bacteria, but very weakly in vitro. Activity tested against Gram- terrestrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
>100 µM

Target

P.aeruginosa

Source & Reference

Antifungipept

Other

but very weakly in vitro. Activity tested against Gram- terrestrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM),
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µM

Target

Y.ruckeri

Source & Reference

Antifungipept

Other

tested against Gram- terrestrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum
Evidence 15 Activity

Activity

MIC
Antifungal
>100 µM

Target

L.anguillarum

Source & Reference

Antifungipept

Other

estrial E.coli (MIC >100 uM), P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >1
Evidence 16 Activity

Activity

MIC
Antifungal
200 µM

Target

A.salmonicida

Source & Reference

Antifungipept

Other

P.aeruginosa (MIC >100 uM), marine Y.ruckeri (MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MI
Evidence 17 Activity

Activity

MIC
Antifungal
50 µM

Target

C.glutamicum

Source & Reference

Antifungipept

Other

(MIC >100 uM), L.anguillarum (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.diverge
Evidence 18 Activity

Activity

MIC
Antifungal
>100 µM

Target

S.aureus

Source & Reference

Antifungipept

Other

um (MIC >100 uM), A.salmonicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.f
Evidence 19 Activity

Activity

MIC
Antifungal
200 µM

Target

C.maltaromaticum

Source & Reference

Antifungipept

Other

onicida (MIC 200 uM), Gram+ terrestrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remain
Evidence 20 Activity

Activity

MIC
Antifungal
100 µM

Target

C. mobile

Source & Reference

Antifungipept

Other

restrial C.glutamicum (MIC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remains to be tested whether t
Evidence 21 Activity

Activity

MIC
Antifungal
200 µM

Target

C.divergens

Source & Reference

Antifungipept

Other

IC 50 uM), S.aureus (MIC >100 uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remains to be tested whether the peptide is more active
Evidence 22 Activity

Activity

MIC
Antifungal
200 µM

Target

C.funditum

Source & Reference

Antifungipept

Other

uM), C.maltaromaticum (MIC 200 uM), C. mobile (MIC 100 uM), C.divergens (MIC 200 uM), and C.funditum (MIC 200 uM). It remains to be tested whether the peptide is more active at low temperature where the