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Peptide record

TPDB11766

Antibacterial Anticancer Antifungal Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB11766
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 38-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RRGLFKKLRRKIKKGFKKIFKRLPPVGVGVSIPLAGRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C205H359N67O40
NDCEQHMTWY
K
4402.53
13.19
15
0
14
+15
2.37
-0.495
97.37
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
7
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
3
I
4
L
8
K
0
M
3
F
3
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 3 L: 4 K: 8 M: 0 F: 3 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
38 reviewed residue count
C205H359N67O40 sequence-only estimate (linear, free termini)
4402.53 sequence-only estimate (linear, free termini)
13.19 sequence-only estimate (linear, free termini)
+15 sequence-only estimate (linear, free termini)
2.37 sequence-only estimate (linear, free termini)
-0.495 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- bacteria E. coli, S. dysenteriae, K. pneumoniae, K. oxytoca, P. vulgaris, P. mirabilis, A. baumannii, S. maltophilia, and P. aeruginosa, Gram+ bacteria S. aureus, B. cereus, E. faecium, and S. epidermidis, and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. harveyi, V. parahaemdyticus, V. anguillarum, and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml, it showed only 4% hemolysis (human red blood cells).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- bacteria E. coli, S. dysenteriae, K. pneumoniae, K. oxytoca, P. vulgaris, P. mirabilis, A. baumannii, S. maltophilia, and P. aeruginosa, Gram+ bacteria S. aureus, B. cereus, E. faecium, and S. epidermidis, and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. harveyi, V. parahaemdyticus, V. anguillarum, and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml, it showed only 4% hemolysis (human red blood cells).
Evidence 3 Activity

Activity

55±2.5% Cell death
Toxicity
200 µg/mL
Cytotoxic
55±2.5% Cell death | 200 | µg/mL | target cell: Chinese hamster ovary cells CHO

Target

Chinese hamster ovary cells CHO

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 4 Activity

Activity

17±1.5% Cell death
Toxicity
200 µg/mL
Cytotoxic
17±1.5% Cell death | 200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 5 Activity

Activity

4±0.5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
4±0.5% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
0.5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 4±0.5% Hemolysis=200µg/ml | Cytotoxicity: CHO: 55±2.5% Cell death=200µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2017 Aug 10 474(16):2861-2885.