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Peptide record

TPDB11763

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

38 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11763

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC

FASTA

>TPDB11763|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=38
GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC

Formula C168H293N47O48S2

Absent Amino Acids RDHMPWY

Common Amino Acids G

Mass 3803.58

PI 10.27

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 15

Net Charge +5

Boman Index 5.34

Hydrophobicity 0.442

Aliphatic Index 112.63

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.29

Polar Residues 9

number

Amino Acid Distribution

A: 2 R: 0 N: 2 D: 0 C: 2 E: 1 Q: 1 G: 7 H: 0 I: 1 L: 5 K: 6 M: 0 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 6

Length

Formula

C168H293N47O48S2

Mass

3803.58

10.27

Net Charge

Boman Index

5.34

Hydrophobicity

0.442

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.8 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dyse

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13.6 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pn

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13.6 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mira

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13.6 µM

Target

Target Organism S. dysenteriae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeru

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16.8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism P.aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13.6 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.8 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dyse

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13.6 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pn

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13.6 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13.6 µM

Target

Target Organism S. dysenteriae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16.8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism P.aeruginosa

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13.6 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.8 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dyse

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13.6 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pn

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13.6 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13.6 µM

Target

Target Organism S. dysenteriae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16.8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism P.aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13.6 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.8 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dyse

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13.6 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against M. luteus (MIC 1.8 uM), S. aureus (MIC 6.8 uM), B. subtilis (MIC 13.6 uM), S. epidermidis (MIC 13.6 uM), S. dysenteriae (MIC 13.6 uM), E. coli (MIC 16.8 uM), K. pn

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13.6 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13.6 µM

Target

Target Organism S. dysenteriae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16.8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism P.aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

.6 uM), E. coli (MIC 16.8 uM), K. pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13.6 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

pneumoniae (MIC 13.6 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 13.6 ug/ml).