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Peptide record

TPDB11741

Antibacterial Anticancer Antifungal Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11741
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 dbACP iACP-DRLF Antifungipept
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIEKMGRNIRDGIVKAGPAIEVLGSAKAIGK
Physicochemical Analysis
C185H317N55O46S1
CQHTY
K
4079.95
11.21
10
3
16
+7
9.51
-0.243
100.27
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
134.81
2
Residue Composition
number
4
A
3
R
1
N
1
D
0
C
2
E
0
Q
5
G
0
H
6
I
1
L
7
K
1
M
1
F
1
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 0 E: 2 Q: 0 G: 5 H: 0 I: 6 L: 1 K: 7 M: 1 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
37
C185H317N55O46S1
4079.95
11.21
+7
9.51
-0.243
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.43 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram-negative bacteria E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. s
Evidence 2 Activity

Activity

MIC
Antibacterial
1.97 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

Active against Gram-negative bacteria E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaen
Evidence 3 Activity

Activity

MIC
Antibacterial
3.21 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP

Other

nst Gram-negative bacteria E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-
Evidence 4 Activity

Activity

MIC
Antibacterial
1.43 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP

Other

E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus
Evidence 5 Activity

Activity

MIC
Antibacterial
2.89 µM

Target

S. sonnei

Source & Reference

dbAMP DRAMP

Other

uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ributio
Evidence 6 Activity

Activity

MIC
Antibacterial
4.62 µM

Target

K. ozaenae

Source & Reference

dbAMP DRAMP

Other

1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epider
Evidence 7 Activity

Activity

MIC
Antibacterial
1.81 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

C 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epidermidis (MIC 5.76 uM). It also displayed anticancer ac
Evidence 8 Activity

Activity

MIC
Antibacterial
2.48 µM

Target

D. ribution

Source & Reference

dbAMP DRAMP

Other

C 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epidermidis (MIC 5.76 uM). It also displayed anticancer activity ( Xia L et al., 2014
Evidence 9 Activity

Activity

MIC
Antibacterial
5.76 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epidermidis (MIC 5.76 uM). It also displayed anticancer activity ( Xia L et al., 2014 ).
Evidence 10 Activity

Activity

MIC
Antifungal
1.43 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram-negative bacteria E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. s
Evidence 11 Activity

Activity

MIC
Antifungal
1.97 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against Gram-negative bacteria E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaen
Evidence 12 Activity

Activity

MIC
Antifungal
3.21 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP Antifungipept

Other

nst Gram-negative bacteria E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-
Evidence 13 Activity

Activity

MIC
Antifungal
1.43 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP Antifungipept

Other

E. coli ATCC 25922 (MIC 1.43 uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus
Evidence 14 Activity

Activity

MIC
Antifungal
2.89 µM

Target

S. sonnei

Source & Reference

dbAMP DRAMP Antifungipept

Other

uM), K. pneumoniae (MIC 1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ributio
Evidence 15 Activity

Activity

MIC
Antifungal
4.62 µM

Target

K. ozaenae

Source & Reference

dbAMP DRAMP Antifungipept

Other

1.97 uM), S. flexneri (MIC 3.21 uM), A. baumannii (MIC 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epider
Evidence 16 Activity

Activity

MIC
Antifungal
1.81 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

C 1.43 uM), S. sonnei (MIC 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epidermidis (MIC 5.76 uM). It also displayed anticancer ac
Evidence 17 Activity

Activity

MIC
Antifungal
2.48 µM

Target

D. ribution

Source & Reference

dbAMP DRAMP Antifungipept

Other

C 2.89 uM), K. ozaenae (MIC 4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epidermidis (MIC 5.76 uM). It also displayed anticancer activity ( Xia L et al., 2014
Evidence 18 Activity

Activity

MIC
Antifungal
5.76 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP Antifungipept

Other

4.62 uM), and Gram-positive bacteria S. aureus (MIC 1.81 uM), D. ribution (MIC 2.48 uM), S. epidermidis (MIC 5.76 uM). It also displayed anticancer activity ( Xia L et al., 2014 ).
Evidence 19 Activity

Activity

5% Hemolysis
Toxicity
77.5 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 77.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A potential food biopreservative, CecXJ-37N, non-covalently intercalates into the nucleotides of bacterial genomic DNA beyond membrane attack. | Food Chem | 2017
Evidence 20 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
A potential food biopreservative, CecXJ-37N, non-covalently intercalates into the nucleotides of bacterial genomic DNA beyond membrane attack. | Food Chem | 2017
Evidence 21 Activity

Activity

37% Killing
Toxicity
100 µg/mL
Cytotoxic
37% Killing | 100 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Antibacterial Activity of Rationally Designed Antimicrobial Peptides. | Int J Microbiol | 2020
Evidence 22 Activity

Activity

5% Hemolysis
Toxicity
134.6 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 134.6 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A potential food biopreservative, CecXJ-37N, non-covalently intercalates into the nucleotides of bacterial genomic DNA beyond membrane attack. | Food Chem | 2017