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Peptide record

TPDB11736

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11736
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ARLKKCFNKVTGYCRKKCKVGERYEIGCLSGKLCCAN
Physicochemical Analysis
C178H301N55O48S6
DQHMPW
K
4172.05
9.74
10
2
11
+8
7.91
-0.400
63.24
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3355
80.42
12
Residue Composition
number
2
A
3
R
2
N
0
D
6
C
2
E
0
Q
4
G
0
H
1
I
3
L
7
K
0
M
1
F
0
P
1
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 0 C: 6 E: 2 Q: 0 G: 4 H: 0 I: 1 L: 3 K: 7 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
37
C178H301N55O48S6
4172.05
9.74
+8
7.91
-0.400
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
37.5 µg/mL

Target

Escherichia coli DSM1103

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus A
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Klebsiella pneumoniae DSM681

Source & Reference

dbAMP DRAMP

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneum
Evidence 3 Activity

Activity

MIC
Antibacterial
37.5 µg/mL

Target

Pseudomonas aeruginosa DSM1128

Source & Reference

dbAMP DRAMP

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
37.5 µg/mL

Target

S. pneumoniae DSM11865

Source & Reference

dbAMP DRAMP

Other

0 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
37.5 µg/mL

Target

Escherichia coli DSM1103

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus A
Evidence 7 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Klebsiella pneumoniae DSM681

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneum
Evidence 8 Activity

Activity

MIC
Antifungal
37.5 µg/mL

Target

Pseudomonas aeruginosa DSM1128

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
37.5 µg/mL

Target

S. pneumoniae DSM11865

Source & Reference

dbAMP DRAMP Antifungipept

Other

0 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 11 Activity

Activity

MIC
Antiparasitic
37.5 µg/mL

Target

Escherichia coli DSM1103

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus A
Evidence 12 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

Klebsiella pneumoniae DSM681

Source & Reference

DRAMP

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneum
Evidence 13 Activity

Activity

MIC
Antiparasitic
37.5 µg/mL

Target

Pseudomonas aeruginosa DSM1128

Source & Reference

DRAMP

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 14 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiparasitic
37.5 µg/mL

Target

S. pneumoniae DSM11865

Source & Reference

DRAMP

Other

0 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 16 Activity

Activity

MIC
Antiviral
37.5 µg/mL

Target

Escherichia coli DSM1103

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus A
Evidence 17 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

Klebsiella pneumoniae DSM681

Source & Reference

DRAMP

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneum
Evidence 18 Activity

Activity

MIC
Antiviral
37.5 µg/mL

Target

Pseudomonas aeruginosa DSM1128

Source & Reference

DRAMP

Other

Active against E. coli DSM1103 (MIC 37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

37.5 ug/ml), K. pneumoniae DSM681 (MIC 50 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 20 Activity

Activity

MIC
Antiviral
37.5 µg/mL

Target

S. pneumoniae DSM11865

Source & Reference

DRAMP

Other

0 ug/ml), P. aeruginosa DSM1128 (MIC 37.5 ug/ml), S. aureus ATCC25923 (MIC 25 ug/ml), and S. pneumoniae DSM11865 (MIC 37.5 ug/ml).
Evidence 21 Activity

Activity

1% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 22 Activity

Activity

2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 23 Activity

Activity

7% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 24 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 µg/ml.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biopolymers. 2005 80(1):34-49.