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Peptide record

TPDB11735

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11735
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SRWPSPGRPRPFPGRPKPIFRPRPCNCYAPPCPCDRW
Physicochemical Analysis
C196H292N62O44S4
EQHLMTV
P
4349.10
11.10
8
1
7
+7
5.65
-1.222
13.24
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
12740
292.93
8
Residue Composition
number
1
A
7
R
1
N
1
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
2
F
12
P
2
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 7 N: 1 D: 1 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 2 P: 12 S: 2 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
37
C196H292N62O44S4
4349.10
11.10
+7
5.65
-1.222
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

L. anguillarum

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Natural and synthetic arasin 1 displayed similar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

arasin 1 displayed similar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 3 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

C. glutamicum

Source & Reference

dbAMP DRAMP

Other

lar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 4 Activity

Activity

MIC
Antifungal
6.3 µM

Target

L. anguillarum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Natural and synthetic arasin 1 displayed similar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 5 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

arasin 1 displayed similar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 6 Activity

Activity

MIC
Antifungal
0.8 µM

Target

C. glutamicum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 7 Activity

Activity

MIC
Antiparasitic
6.3 µM

Target

L. anguillarum

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Natural and synthetic arasin 1 displayed similar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 8 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

arasin 1 displayed similar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.8 µM

Target

C. glutamicum

Source & Reference

DRAMP

Other

lar activity profiles. Active against L. anguillarum (MIC 6.3 uM), E. coli (MIC 12.5 uM), C. glutamicum (MIC 0.8 uM). However, MBC values are much higher.
Evidence 10 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of the antimicrobial peptide arasin 1 - and mode of action studies of the N-terminal, proline-rich region. | PLoS One | 2013