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Peptide record

TPDB11733

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11733
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLGNFFRKAKKKIGRGLKKIGQKIKDFLGNLVPRTES
Physicochemical Analysis
C193H330N60O47
CHMWY
K
4243.12
12.05
12
2
12
+10
9.94
-0.776
84.32
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
5
Residue Composition
number
1
A
4
R
2
N
1
D
0
C
1
E
1
Q
5
G
0
H
3
I
4
L
8
K
0
M
3
F
1
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 2 D: 1 C: 0 E: 1 Q: 1 G: 5 H: 0 I: 3 L: 4 K: 8 M: 0 F: 3 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
37
C193H330N60O47
4243.12
12.05
+10
9.94
-0.776
Evidence Records 3 records
Evidence 1 Activity

Activity

55% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
55% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity | J Biol Chem | 2006
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
20% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity | J Biol Chem | 2006
Evidence 3 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.