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Peptide record

TPDB11731

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11731
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLMSLFRGVLKTAGKHIFKNVGGSLLDQAKCKITGEC
Physicochemical Analysis
C173H291N49O48S3
PWY
G
3921.69
10.06
7
2
14
+4
4.98
0.159
94.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.19
8
Residue Composition
number
2
A
1
R
1
N
1
D
2
C
1
E
1
Q
6
G
1
H
2
I
5
L
5
K
1
M
2
F
0
P
2
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 6 H: 1 I: 2 L: 5 K: 5 M: 1 F: 2 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C173H291N49O48S3
3921.69
10.06
+4
4.98
0.159
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 8 Activity

Activity

MIC
Antifungal
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 9 Activity

Activity

MIC
Antifungal
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 13 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 14 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 15 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 16 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 17 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 18 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

C.albicans

Source & Reference

DRAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 19 Activity

Activity

MIC
Antiviral
3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 20 Activity

Activity

MIC
Antiviral
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 21 Activity

Activity

MIC
Antiviral
6 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 22 Activity

Activity

MIC
Antiviral
6 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 23 Activity

Activity

MIC
Antiviral
25 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 24 Activity

Activity

MIC
Antiviral
>100 µM

Target

C.albicans

Source & Reference

DRAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM).
Evidence 25 Activity

Activity

HC50
Hemolysis
55 µM
[Ref.15003829] HC50=55 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Regul Pept. 2004 May 15 118(3):135-141.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
65 µM
Hemolytic Cytotoxic
50% Hemolysis | 65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. | Regul Pept | 2004
Evidence 27 Activity

Activity

HC50
Toxicity
55 µM
Hemolytic
Hemolytic_activity: [Ref.15003829] HC50=55 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2004 May 15 118(3):135-141.
Evidence 28 Hemolysis

Activity

55 µM
HC50
[Ref.15003829] HC50=55 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Regul Pept. 2004 May 15 118(3):135-141.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.