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Peptide record

TPDB11727

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11727
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GGYYCPFRQDKCHRHCRSFGRKAGYCGGFLKKTCICV
Physicochemical Analysis
C185H282N58O46S6
NEMW
CG
4247.00
9.49
10
1
10
+7
3.09
-0.505
31.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
114.08
12
Residue Composition
number
1
A
4
R
0
N
1
D
6
C
0
E
1
Q
6
G
2
H
1
I
1
L
4
K
0
M
3
F
1
P
1
S
1
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 1 C: 6 E: 0 Q: 1 G: 6 H: 2 I: 1 L: 1 K: 4 M: 0 F: 3 P: 1 S: 1 T: 1 W: 0 Y: 3 V: 1
Chemical Descriptors
37
C185H282N58O46S6
4247.00
9.49
+7
3.09
-0.505
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA. Kill in 60 min. Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA.Kill in 60 min.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA. Kill in 60 min. Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA.Kill in 60 min.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA. Kill in 60 min. Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA.Kill in 60 min.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA. Kill in 60 min. Primarily active against S. xylasus, M. lutes, B. subtilis, MRSA.Kill in 60 min.
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
2.0 64.6 %
[Ref.21504572] It has 2.0% and 64.6% hemolysis at concentrations of 12.5 µM and 100 µM against human erythrocytes .

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Parasit Vectors. 2011 Apr 19 4(1):63.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

2% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
2% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus. | Parasit Vectors | 2011
Evidence 7 Activity

Activity

65% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
65% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus. | Parasit Vectors | 2011
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
64.6 %
Hemolytic
Hemolytic_activity: [Ref.21504572] It has 2.0% and 64.6% hemolysis at concentrations of 12.5 µM and 100 µM against human erythrocytes .

Target

erythrocytes

Source & Reference

NA
DRAMP
Parasit Vectors. 2011 Apr 19 4(1):63.
Evidence 9 Hemolysis

Activity

2.0 64.6 %
% Hemolysis
[Ref.21504572] It has 2.0% and 64.6% hemolysis at concentrations of 12.5 µM and 100 µM against human erythrocytes .
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Parasit Vectors. 2011 Apr 19 4(1):63.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.