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Peptide record

TPDB11724

Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11724
Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 dbAMP DRAMP ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
DHYICAKKGGTCNFSPCPLFNRIEGTCYSGKAKCCIR
Physicochemical Analysis
C175H275N51O50S6
QMWV
C
4085.78
8.57
7
2
10
+4
4.70
-0.289
47.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
3355
82.11
14
Residue Composition
number
2
A
2
R
2
N
1
D
6
C
1
E
0
Q
4
G
1
H
3
I
1
L
4
K
0
M
2
F
2
P
2
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 1 I: 3 L: 1 K: 4 M: 0 F: 2 P: 2 S: 2 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
37
C175H275N51O50S6
4085.78
8.57
+4
4.70
-0.289
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
This synthetic peptide is most active against S. typhimurium in vitro and in vivo, L. monocytogenes, S. aureus, and E. rhusiopathiae. pBD-2 (4-8 uM) killed these pathogens within 3 h. antiinflammatory activity may result from a direct interaction of pBD-2 with TLR-4 rather than LPS binding.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
This synthetic peptide is most active against S. typhimurium in vitro and in vivo, L. monocytogenes, S. aureus, and E. rhusiopathiae. pBD-2 (4-8 uM) killed these pathogens within 3 h. antiinflammatory activity may result from a direct interaction of pBD-2 with TLR-4 rather than LPS binding.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

This synthetic peptide is most active against S. typhimurium in vitro and in vivo, L. monocytogenes, S. aureus, and E. rhusiopathiae. pBD-2 (4-8 uM) killed these pathogens within 3 h. antiinflammatory activity may result from a direct interaction of pBD-2 with TLR-4 rather than LPS binding.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

This synthetic peptide is most active against S. typhimurium in vitro and in vivo, L. monocytogenes, S. aureus, and E. rhusiopathiae. pBD-2 (4-8 uM) killed these pathogens within 3 h. antiinflammatory activity may result from a direct interaction of pBD-2 with TLR-4 rather than LPS binding.
Evidence 5 Activity

Activity

12% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 80 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning, expression and characterization of the porcine beta defensin 2 in E. coli. | Protein Pept Lett | 2013
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.