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Peptide record

TPDB11723

Calcitonin gene-related peptide 1 Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11723
Calcitonin gene-related peptide 1
Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Neuroactive peptides
AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF
Physicochemical Analysis
C163H268N50O50S2
EQIMWY
V
3792.35
9.92
5
1
14
+3
3.74
0.211
81.62
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
3.30
12
Residue Composition
number
4
A
2
R
3
N
1
D
2
C
0
E
0
Q
4
G
1
H
0
I
3
L
2
K
0
M
2
F
1
P
3
S
4
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 4 R: 2 N: 3 D: 1 C: 2 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 2 M: 0 F: 2 P: 1 S: 3 T: 4 W: 0 Y: 0 V: 5
Chemical Descriptors
37
C163H268N50O50S2
3792.35
9.92
+3
3.74
0.211
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.1 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
It showed a good activity against E. coli ATCC 25922 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC
Evidence 2 Activity

Activity

MIC
Antibacterial
5.9 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

It showed a good activity against E. coli ATCC 25922 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC 3179 (MIC 63 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
63 µg/mL

Target

Candida albicans NCTC 3179

Source & Reference

dbAMP

Other

2 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC 3179 (MIC 63 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
2.1 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
It showed a good activity against E. coli ATCC 25922 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC
Evidence 5 Activity

Activity

MIC
Antifungal
5.9 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

It showed a good activity against E. coli ATCC 25922 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC 3179 (MIC 63 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
63 µg/mL

Target

Candida albicans NCTC 3179

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC 3179 (MIC 63 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
2.1 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

It showed a good activity against E. coli ATCC 25922 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC
Evidence 8 Activity

Activity

MIC
Antiparasitic
5.9 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

It showed a good activity against E. coli ATCC 25922 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC 3179 (MIC 63 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
63 µg/mL

Target

Candida albicans NCTC 3179

Source & Reference

NA

Other

2 (MIC 2.1 ug/ml) and P. aeruginosa ATCC 27853 (MIC 5.9 ug/ml), moderate activity against C. albicans NCTC 3179 (MIC 63 ug/ml).
Evidence 10 Activity

Activity

Neuropeptide

Target

Calcitonin gene-related peptide type 1 receptor Receptor activity-modifying protein 2 Receptor activity-modifying protein 3 Receptor activity-modifying protein 1
Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Calcitonin
461 175 148 148
NP00061 NP00047 NP00065 NP00056 NP00052 NP01795 NP01799 NP00047 NP00052 NP01795 NP01799 NP00047 NP00052 NP01795 NP01799 NP00056 NP00052 NP01795 NP01799
Evidence 11 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human pulp fibroblasts

Target

Human pulp fibroblasts

Source & Reference

NA
DBAASP
Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. | J Neuroimmunol | 2008
Additional Detail Fields 3 fields
Calcitonin
461 175 148
NP00061 NP00047 NP00065 NP00056 NP00052 NP01795 NP01799