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Peptide record

TPDB11722

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11722
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLGNFFRKVKEKIGGGLKKVGQKIKDFLGNLVPRTAS
Physicochemical Analysis
C187H316N56O47
CHMWY
K
4100.91
11.66
10
2
13
+8
8.60
-0.454
89.46
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
5
Residue Composition
number
1
A
3
R
2
N
1
D
0
C
1
E
1
Q
6
G
0
H
2
I
4
L
7
K
0
M
3
F
1
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 0 E: 1 Q: 1 G: 6 H: 0 I: 2 L: 4 K: 7 M: 0 F: 3 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
37
C187H316N56O47
4100.91
11.66
+8
8.60
-0.454
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (MIC 0.25-0.5 uM, 20% TSB in SPB 0.25-0.5 uM, 5% TSB in SPB 4 uM, 20TSB in PIL), P. aeruginosa (MIC 0.5 uM, 20% TSB in SPB ND uM, 5% TSB in SPB 8 uM, 20TSB in PIL), S. aureus (MIC 0.5-1 uM, 20% TSB in SPB ND, 5% TSB in SPB 0.5 uM, 20TSB in PIL), E. faecalis (MIC 1-2, 20% TSB in SPB 1-2 uM, 20TSB in PIL), C. albicans (MIC >32 uM, 20% TSB in SPB 16-32 uM, 5% TSB in SPB >32 uM, 20TSB in PIL). Update: ref 10/2012 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (MIC 0.25-0.5 uM, 20% TSB in SPB 0.25-0.5 uM, 5% TSB in SPB 4 uM, 20TSB in PIL), P. aeruginosa (MIC 0.5 uM, 20% TSB in SPB ND uM, 5% TSB in SPB 8 uM, 20TSB in PIL), S. aureus (MIC 0.5-1 uM, 20% TSB in SPB ND, 5% TSB in SPB 0.5 uM, 20TSB in PIL), E. faecalis (MIC 1-2, 20% TSB in SPB 1-2 uM, 20TSB in PIL), C. albicans (MIC >32 uM, 20% TSB in SPB 16-32 uM, 5% TSB in SPB >32 uM, 20TSB in PIL). Update: ref 10/2012 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against E. coli (MIC 0.25-0.5 uM, 20% TSB in SPB 0.25-0.5 uM, 5% TSB in SPB 4 uM, 20TSB in PIL), P. aeruginosa (MIC 0.5 uM, 20% TSB in SPB ND uM, 5% TSB in SPB 8 uM, 20TSB in PIL), S. aureus (MIC 0.5-1 uM, 20% TSB in SPB ND, 5% TSB in SPB 0.5 uM, 20TSB in PIL), E. faecalis (MIC 1-2, 20% TSB in SPB 1-2 uM, 20TSB in PIL), C. albicans (MIC >32 uM, 20% TSB in SPB 16-32 uM, 5% TSB in SPB >32 uM, 20TSB in PIL). Update: ref 10/2012 7/2021
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
100% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity | J Biol Chem | 2006
Evidence 5 Activity

Activity

30% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
30% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity | J Biol Chem | 2006
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.