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Peptide record

TPDB11717

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11717
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLRKRLRKFRNKIKEKLKKIGQKIQGFVPKLAPRTDY
Physicochemical Analysis
C204H352N64O47
CHMSW
K
4453.44
11.96
14
2
12
+12
12.39
-1.114
84.32
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
33.46
5
Residue Composition
number
1
A
5
R
1
N
1
D
0
C
1
E
2
Q
3
G
0
H
3
I
4
L
9
K
0
M
2
F
2
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 3 H: 0 I: 3 L: 4 K: 9 M: 0 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C204H352N64O47
4453.44
11.96
+12
12.39
-1.114
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
This appears to be the first peptide in the cathelicidin family demonstrated to have antibacterial activity against various Gram-positive S. pneumoniae, S. pyogenes, and S. aureus or MRSA and Gram-negative bacteria E. coli HB101, K. pneumoniae, P. aeruginosa, and P. apacia. C-albicans (inactive at 20 ug/ml).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
This appears to be the first peptide in the cathelicidin family demonstrated to have antibacterial activity against various Gram-positive S. pneumoniae, S. pyogenes, and S. aureus or MRSA and Gram-negative bacteria E. coli HB101, K. pneumoniae, P. aeruginosa, and P. apacia. C-albicans (inactive at 20 ug/ml).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

This appears to be the first peptide in the cathelicidin family demonstrated to have antibacterial activity against various Gram-positive S. pneumoniae, S. pyogenes, and S. aureus or MRSA and Gram-negative bacteria E. coli HB101, K. pneumoniae, P. aeruginosa, and P. apacia. C-albicans (inactive at 20 ug/ml).
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Positive selection in cathelicidin host defense peptides: adaptation to exogenous pathogens or endogenous receptors? | Heredity (Edinb) | 2016