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Peptide record

TPDB11716

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11716
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLMSVLKGVLKTAGKHIFKNVGGSLLDQAKCKITGQC
Physicochemical Analysis
C169H292N48O47S3
REPWY
GK
3844.65
10.27
7
1
14
+5
4.92
0.214
102.70
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.25
9
Residue Composition
number
2
A
0
R
1
N
1
D
2
C
0
E
2
Q
6
G
1
H
2
I
5
L
6
K
1
M
1
F
0
P
2
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 2 E: 0 Q: 2 G: 6 H: 1 I: 2 L: 5 K: 6 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
37
C169H292N48O47S3
3844.65
10.27
+5
4.92
0.214
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100
Evidence 4 Activity

Activity

MIC
Antibacterial
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/202
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 7 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 8 Activity

Activity

MIC
Antifungal
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans
Evidence 9 Activity

Activity

MIC
Antifungal
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100
Evidence 10 Activity

Activity

MIC
Antifungal
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/202
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 12 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 13 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 14 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans
Evidence 15 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100
Evidence 16 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/202
Evidence 17 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 18 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 19 Activity

Activity

MIC
Antiviral
3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 20 Activity

Activity

MIC
Antiviral
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans
Evidence 21 Activity

Activity

MIC
Antiviral
6 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100
Evidence 22 Activity

Activity

MIC
Antiviral
6 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/202
Evidence 23 Activity

Activity

MIC
Antiviral
25 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

li (MIC 3 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 24 Activity

Activity

MIC
Antiviral
100 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 100 uM. Updated 11/2019 7/2021
Evidence 25 Activity

Activity

HC50
Hemolysis
100 µM
[Ref.15003829] HC50=100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Regul Pept. 2004 May 15 118(3):135-141.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. | Regul Pept | 2004
Evidence 27 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref.15003829] HC50=100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2004 May 15 118(3):135-141.
Evidence 28 Hemolysis

Activity

100 µM
HC50
[Ref.15003829] HC50=100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Regul Pept. 2004 May 15 118(3):135-141.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.