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Peptide record

TPDB11715

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11715
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLMSLFKGVLKTAGKHIFKNVGGSLLDQAKCKITGEC
Physicochemical Analysis
C173H291N47O48S3
RPWY
GK
3893.68
9.98
7
2
14
+4
5.16
0.176
94.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.21
8
Residue Composition
number
2
A
0
R
1
N
1
D
2
C
1
E
1
Q
6
G
1
H
2
I
5
L
6
K
1
M
2
F
0
P
2
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 6 H: 1 I: 2 L: 5 K: 6 M: 1 F: 2 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C173H291N47O48S3
3893.68
9.98
+4
5.16
0.176
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM
Evidence 4 Activity

Activity

MIC
Antibacterial
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptid
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

li (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 n
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.albicans

Source & Reference

dbAMP

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 nmol/g weight of dry skin) sho
Evidence 7 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 8 Activity

Activity

MIC
Antifungal
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 9 Activity

Activity

MIC
Antifungal
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM
Evidence 10 Activity

Activity

MIC
Antifungal
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptid
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

li (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 n
Evidence 12 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 nmol/g weight of dry skin) sho
Evidence 13 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 14 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 15 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Enterobacter cloacae

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM
Evidence 16 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptid
Evidence 17 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

li (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 n
Evidence 18 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

C.albicans

Source & Reference

NA

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 nmol/g weight of dry skin) sho
Evidence 19 Activity

Activity

MIC
Antiviral
6 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MI
Evidence 20 Activity

Activity

MIC
Antiviral
3 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (
Evidence 21 Activity

Activity

MIC
Antiviral
6 µM

Target

Enterobacter cloacae

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM
Evidence 22 Activity

Activity

MIC
Antiviral
6 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against E. coli (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptid
Evidence 23 Activity

Activity

MIC
Antiviral
25 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

li (MIC 6 uM), P. aeruginosa (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 n
Evidence 24 Activity

Activity

MIC
Antiviral
>100 µM

Target

C.albicans

Source & Reference

NA

Other

a (MIC 3 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. aureus (MIC 25 uM), and C.albicans (MIC>100 uM). HC50 55 uM. The most abundant peptide, brevinin-2PRa (680 nmol/g weight of dry skin) sho
Evidence 25 Activity

Activity

50% Hemolysis
Toxicity
55 µM
Hemolytic Cytotoxic
50% Hemolysis | 55 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. | Regul Pept | 2004
Evidence 26 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.