TPDB11714

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against Gram+ S. aureus ATCC25923 or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis LY8

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

against Gram+ S. aureus ATCC25923 or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-125 µg/mL

Target

Target Organism L. monocytogenes CICC21634 or CICC21533

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µg/mL

Target

Target Organism B. subtilis CICC24434

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

pidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium S

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.6 µM

Target

Target Organism B. Globigii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

togenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µg/mL

Target

Target Organism S. choleraesuis C78-1

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesu

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12-4 µg/mL

Target

Target Organism S. typhimurium SL1344

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µg/mL

Target

Target Organism P. avium C48-3

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aerugino

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µg/mL

Target

Target Organism S. choleraesuis C78-1

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1-2 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM). Anti-inflammatory: Bind LPS, sup

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.25-2.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM). Anti-inflammatory: Bind LPS, suppress LPS-induced cytokines IL-6 and TNF-alpha. Viruses:

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against Gram+ S. aureus ATCC25923 or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis LY8

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

against Gram+ S. aureus ATCC25923 or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-125 µg/mL

Target

Target Organism L. monocytogenes CICC21634 or CICC21533

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µg/mL

Target

Target Organism B. subtilis CICC24434

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

pidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium S

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.6 µM

Target

Target Organism B. Globigii

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

togenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml),

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µg/mL

Target

Target Organism S. choleraesuis C78-1

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesu

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12-4 µg/mL

Target

Target Organism S. typhimurium SL1344

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

(MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µg/mL

Target

Target Organism P. avium C48-3

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

, Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aerugino

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µg/mL

Target

Target Organism S. choleraesuis C78-1

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

C 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1-2 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

C 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM). Anti-inflammatory: Bind LPS, sup

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.25-2.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM). Anti-inflammatory: Bind LPS, suppress LPS-induced cytokines IL-6 and TNF-alpha. Viruses:

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against Gram+ S. aureus ATCC25923 or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis LY8

Source & Reference

Database Source DRAMP

Other

Evidence Text

against Gram+ S. aureus ATCC25923 or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4-125 µg/mL

Target

Target Organism L. monocytogenes CICC21634 or CICC21533

Source & Reference

Database Source DRAMP

Other

Evidence Text

or Cowan 1 (MIC 32-64), B. megaterium Bm11 (MIC 4 uM), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.56 µg/mL

Target

Target Organism B. subtilis CICC24434

Source & Reference

Database Source DRAMP

Other

Evidence Text

pidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium S

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.6 µM

Target

Target Organism B. Globigii

Source & Reference

Database Source DRAMP

Other

Evidence Text

togenes CICC21634 or CICC21533 (MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml),

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.56 µg/mL

Target

Target Organism S. choleraesuis C78-1

Source & Reference

Database Source DRAMP

Other

Evidence Text

MIC 4-125 ug/ml), B. subtilis CICC24434 (MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesu

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.12-4 µg/mL

Target

Target Organism S. typhimurium SL1344

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 1.56 ug/ml), B. Globigii (MIC 0.6 uM), Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.12 µg/mL

Target

Target Organism P. avium C48-3

Source & Reference

Database Source DRAMP

Other

Evidence Text

, Gram- S. choleraesuis C78-1 (MIC 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aerugino

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.56 µg/mL

Target

Target Organism S. choleraesuis C78-1

Source & Reference

Database Source DRAMP

Other

Evidence Text

C 1.56 ug/ml), S. typhimurium SL1344 (MIC 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM).

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1-2 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

C 3.12-4 ug/ml), P. avium C48-3 (MIC 3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM). Anti-inflammatory: Bind LPS, sup

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.25-2.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

Database Source DRAMP

Other

Evidence Text

3.12 ug/ml), S. choleraesuis C78-1 (MIC 1.56 ug/ml), E. coli ATCC 25922 (MIC 1-2 uM), and P. aeruginosa ATCC 27853 or PAO1 (MIC 1.25-2.5 uM). Anti-inflammatory: Bind LPS, suppress LPS-induced cytokines IL-6 and TNF-alpha. Viruses:

Evidence 34 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity. | Eur J Biochem | 1995

Evidence 35 Activity

Activity

Activity Endpoint 30% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

30% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity. | Eur J Biochem | 1995

Evidence 36 Activity

Activity

Activity Endpoint <4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1000 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<4% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Enhancing the antibacterial activity of PMAP-37 by increasing its hydrophobicity. | Chem Biol Drug Des | 2019

Evidence 37 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Enhancing the antibacterial activity of PMAP-37 by increasing its hydrophobicity. | Chem Biol Drug Des | 2019

Evidence 38 Activity

Activity

Activity Endpoint <5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1000 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<5% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial Peptide PMAP-37 Analogs: Increasing the Positive Charge to Enhance the Antibacterial Activity of PMAP-37. | J Pept Sci | 2019

Evidence 39 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.