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Peptide record

TPDB11712

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11712
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic Hemolytic2
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKLSGISKVLRAIAKFFKGVGKARKQFKEASDLDKNQ
Physicochemical Analysis
C183H308N54O50
CHMPTWY
K
4064.79
10.97
10
3
14
+7
9.80
-0.562
79.19
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
4
A
2
R
1
N
2
D
0
C
1
E
2
Q
4
G
0
H
2
I
3
L
8
K
0
M
3
F
0
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 2 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 2 L: 3 K: 8 M: 0 F: 3 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C183H308N54O50
4064.79
10.97
+7
9.80
-0.562
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
6.2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
6.2 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 7 Activity

Activity

% Hemolysis
Hemolysis
10 %
[Ref.11976325]10% hemolytic activity at 50 µM against sheep red blood cells

Target

sheep red blood cells

Source & Reference

APD_complete APD_hemolytic
DRAMP4
J Biol Chem. 2002 Jun 28 277(26):23627-23637.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 8 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11976325]10% hemolytic activity at 50 µM against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2002 Jun 28 277(26):23627-23637.
Evidence 9 Hemolysis

Activity

10 %
% Hemolysis
[Ref.11976325]10% hemolytic activity at 50 µM against sheep red blood cells
Hemolysis

Target

sheep red blood cells

Source & Reference

APD_complete APD_hemolytic
J Biol Chem. 2002 Jun 28 277(26):23627-23637.
DRAMP4
APD_complete APD_hemolytic