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Peptide record

TPDB11711

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity standard

37 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11711

Activity

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC

FASTA

>TPDB11711|Antibacterial;Anticancer;Antidiabetic;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=37
GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC

Formula C173H289N47O47S2

Absent Amino Acids NEHMPTWY

Common Amino Acids K

Mass 3843.60

PI 10.27

Basic Residues 7

Acidic Residues 2

Hydrophobic Residues 16

Net Charge +5

Boman Index 3.16

Hydrophobicity 0.373

Aliphatic Index 97.57

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.25

Polar Residues 7

number

Amino Acid Distribution

A: 4 R: 1 N: 0 D: 2 C: 2 E: 0 Q: 1 G: 5 H: 0 I: 2 L: 4 K: 6 M: 0 F: 3 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C173H289N47O47S2

Mass

3843.60

10.27

Net Charge

Boman Index

3.16

Hydrophobicity

0.373

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MR

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MRSA) (MIC 5 uM), A. baumannii (MIC 5 u

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MRSA) (MIC 5 uM), A. baumannii (MIC 5 uM), and S. maltophilia (MIC Ojo et al.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MRSA) (MIC 5 uM), A. baumannii (MIC 5 uM), and S. maltophilia (MIC Ojo et al., 2015 ), thereby of interest for type 2 diabetes (T2D

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MR

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MRSA) (MIC 5 uM), A. baumannii (MIC 5 u

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MR

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Bacteria E. coli (MIC 5 uM), P. aeruginosa ATCC 27853 (MIC 5 uM), K. pneumoniae ATCC 700603 (MIC 5 uM), S. aureus (MRSA) (MIC 5 uM), A. baumannii (MIC 5 u

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 150 µM

Hemolysis Raw

[Ref.21262304] LC50=150 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2011 Apr 32(4):664-669.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 15 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.21262304] LC50=150 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2011 Apr 32(4):664-669.

Evidence 16 Hemolysis

Activity

Activity Measurement 150 µM

Activity Endpoint LC50

Hemolysis Raw

[Ref.21262304] LC50=150 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Peptides. 2011 Apr 32(4):664-669.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.