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Peptide record

TPDB11710

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11710
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC
Physicochemical Analysis
C165H287N45O49S2
RNEHMPWY
K
3749.49
9.98
6
2
15
+4
5.17
0.330
105.41
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.33
9
Residue Composition
number
4
A
0
R
0
N
2
D
2
C
0
E
2
Q
5
G
0
H
1
I
5
L
6
K
0
M
1
F
0
P
2
S
3
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 2 C: 2 E: 0 Q: 2 G: 5 H: 0 I: 1 L: 5 K: 6 M: 0 F: 1 P: 0 S: 2 T: 3 W: 0 Y: 0 V: 4
Chemical Descriptors
37
C165H287N45O49S2
3749.49
9.98
+4
5.17
0.330
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml)
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

S. dysentariae

Source & Reference

dbAMP DRAMP

Other

MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

P. putida

Source & Reference

dbAMP DRAMP

Other

B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

, K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protoz
Evidence 7 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protozoan A. proteus at 25 ug/ml
Evidence 8 Activity

Activity

MIC
Antifungal
2.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae
Evidence 9 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml),
Evidence 10 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml)
Evidence 11 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

S. dysentariae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MI
Evidence 12 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

P. putida

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng
Evidence 13 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protoz
Evidence 14 Activity

Activity

MIC
Antifungal
75 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protozoan A. proteus at 25 ug/ml
Evidence 15 Activity

Activity

MIC
Antiparasitic
2.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae
Evidence 16 Activity

Activity

MIC
Antiparasitic
10 µg/mL

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml),
Evidence 17 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against M. luteus (MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml)
Evidence 18 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

S. dysentariae

Source & Reference

dbAMP 3.0 DRAMP

Other

MIC 2.5 ug/ml), S. epidermidis, B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MI
Evidence 19 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

P. putida

Source & Reference

dbAMP 3.0 DRAMP

Other

B. subtilis (MIC 10 ug/ml), K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng
Evidence 20 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

, K. pneumoniae (MIC 25 ug/ml), S. dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protoz
Evidence 21 Activity

Activity

MIC
Antiparasitic
75 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

dysentariae (MIC 25 ug/ml), P. putida (MIC 100 ug/ml), P. aeruginosa (MIC 100 ug/ml) and E. coli (MIC 75 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protozoan A. proteus at 25 ug/ml
Evidence 22 Activity

Activity

1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4 | Biochem Biophys Res Commun | 2007
Evidence 23 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.7999137] It has 0.50% hemolytic activity at 0.1 µg/ml, 0.74% hemolytic activity at 1 µg/ml, 0.78% hemolytic activity at 10 µg/ml, 1.67% hemolytic activity at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1994 Nov 30 205(1):948-954.##Biochem Biophys Res Commun. 2007 Jan 19 352(3):592-597.##Biochim Biophys Acta. 2000 Jun 21 1492(1):185-190.