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Peptide record

TPDB11709

Antibacterial Anticancer Antifungal Antiparasitic standard

37 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11709

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP

Sequence_Type

standard

Has_Modification No

Description A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

DIQIPGIKKPTHRDIIIPNWNPNVRTQPWQRFGGNKS

FASTA

>TPDB11709|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=37
DIQIPGIKKPTHRDIIIPNWNPNVRTQPWQRFGGNKS

Formula C195H306N60O52

Absent Amino Acids ACELMY

Common Amino Acids I

Mass 4322.95

PI 11.46

Basic Residues 7

Acidic Residues 2

Hydrophobic Residues 10

Net Charge +4

Boman Index 8.31

Hydrophobicity -1.057

Aliphatic Index 71.08

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 11000

Absorbance 280nm 254.46

Polar Residues 10

number

Amino Acid Distribution

A: 0 R: 3 N: 4 D: 2 C: 0 E: 0 Q: 3 G: 3 H: 1 I: 6 L: 0 K: 3 M: 0 F: 1 P: 5 S: 1 T: 2 W: 2 Y: 0 V: 1

Length

Formula

C195H306N60O52

Mass

4322.95

11.46

Net Charge

Boman Index

8.31

Hydrophobicity

-1.057

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31.4-55 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wicke

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.3-16.5 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 u

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.3-16.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.3-16.5 µM

Target

Target Organism C. wickerhamii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska et al. 2007 .

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.5-11 µM

Target

Target Organism S. pombe

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

oris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska et al. 2007 .

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31.4-55 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wicke

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.3-16.5 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 u

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.3-16.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.3-16.5 µM

Target

Target Organism C. wickerhamii

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska et al. 2007 .

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.5-11 µM

Target

Target Organism S. pombe

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

oris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska et al. 2007 .

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 31.4-55 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wicke

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.3-16.5 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ M. luteus (MIC 31.4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 u

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.3-16.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.3-16.5 µM

Target

Target Organism C. wickerhamii

Source & Reference

Database Source DRAMP

Other

Evidence Text

4-55 uM), yeast-like fungi P. pastoris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska et al. 2007 .

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5.5-11 µM

Target

Target Organism S. pombe

Source & Reference

Database Source DRAMP

Other

Evidence Text

oris (MIC 8.3-16.5 uM), Z. marxianus (MIC 8.3-16.5 uM), C. wickerhamii (MIC 8.3-16.5 uM), S. pombe (MIC 5.5-11 uM). Activity data from Cytry?ska et al. 2007 .