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Peptide record

TPDB11705

Cecropin A Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11705
Cecropin A
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept dbAMP 3.0 AI4AVP DRAVP 2.0
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK
Physicochemical Analysis
C184H312N52O47
CHMSY
K
4004.82
10.91
8
2
17
+6
8.12
-0.073
108.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
137.33
5
Residue Composition
number
5
A
1
R
1
N
1
D
0
C
1
E
3
Q
4
G
0
H
5
I
1
L
7
K
0
M
1
F
1
P
0
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 3 G: 4 H: 0 I: 5 L: 1 K: 7 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
37
C184H312N52O47
4004.82
10.91
+6
8.12
-0.073
Free
L
Linear
Free
Antimicrobial
Isolated from the giant silk moth Hyalophora cecropia
Evidence Records 16 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against insect pathogens S. marcescens, P. aeruginosa, X. nematophilus, E. coli K12, and B. megaterium, no inhibition: B.subtilis (inhibition zone assays). ActivityG: D=L.
Evidence 2 Activity

Activity

IC50
IC50=1 µM
Anticancer
1 µM

Target

Skin Cancer
SCC12
Skin

Assay & Model

MTT/MTS assay
48-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2014

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 3 Activity

Activity

IC50
IC50=2.2 µM
Anticancer
2.2 µM

Target

Skin Cancer
SCC25
Skin

Assay & Model

MTT/MTS assay
48-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2014
Evidence 4 Activity

Activity

0.6 ± 0.6% cell growth inhibition at 10 µM
Anticancer

Target

Skin Cancer
SCC25
Skin

Assay & Model

Cell Viability assay
48-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2014
Evidence 5 Activity

Activity

107.0 ± 5.0% cell growth inhibition at 1 µM
Anticancer

Target

Skin Cancer
SCC25
Skin

Assay & Model

Cell Viability assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2014
Evidence 6 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against insect pathogens S. marcescens, P. aeruginosa, X. nematophilus, E. coli K12, and B. megaterium, no inhibition: B.subtilis (inhibition zone assays). ActivityG: D=L.
Evidence 7 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against insect pathogens S. marcescens, P. aeruginosa, X. nematophilus, E. coli K12, and B. megaterium, no inhibition: B.subtilis (inhibition zone assays). ActivityG: D=L.
Evidence 8 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against insect pathogens S. marcescens, P. aeruginosa, X. nematophilus, E. coli K12, and B. megaterium, no inhibition: B.subtilis (inhibition zone assays). ActivityG: D=L.
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 256 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Design of hybrid ?-hairpin peptides with enhanced cell specificity and potent anti-inflammatory activity. | Biomaterials | 2013
Evidence 10 Activity

Activity

1% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000
Evidence 11 Activity

Activity

100% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
100% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Temporins, small antimicrobial peptides with leishmanicidal activity. | J Biol Chem | 2005
Evidence 12 Activity

Activity

100% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
100% Hemolysis | >200 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
The plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide. | Biochem J | 1998
Evidence 13 Activity

Activity

50% Cell death
Toxicity
>50 µM
Cytotoxic
50% Cell death | >50 | µM | target cell: Mouse fibroblasts 3T6

Target

Mouse fibroblasts 3T6

Source & Reference

NA
DBAASP
Conformational study of a custom antibacterial peptide cecropin B1: implications of the lytic activity. | Biochim Biophys Acta | 2000
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conformational study of a custom antibacterial peptide cecropin B1: implications of the lytic activity. | Biochim Biophys Acta | 2000
Evidence 15 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 16 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic
Hemolytic_activity: [Ref.29925795] 50% hemolysis at 169 ± 8.20 µg/ml against sheep red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 1982 Sep 127(1):207-217.##Molecules. 2018 Jun 20 23(6):1491.