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Peptide record

TPDB11704

Antibacterial Antifungal Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11704
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIMRVFKGVLKTAGKSVAKNVAGSFLDRLKCKISGGC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C169H292N50O45S3
EQHPWY
GK
3840.67
10.81
8
1
15
+7
0.77
0.276
92.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
0.03
7
Residue Composition
number
3
A
2
R
1
N
1
D
2
C
0
E
0
Q
6
G
0
H
2
I
3
L
6
K
1
M
2
F
0
P
3
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 3 K: 6 M: 1 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
37 reviewed residue count
C169H292N50O45S3 sequence-only estimate (linear, free termini)
3840.67 sequence-only estimate (linear, free termini)
10.81 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
0.77 sequence-only estimate (linear, free termini)
0.276 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
52 µM
Hemolytic Cytotoxic
50% Hemolysis | 52 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and functional characterization of novel antimicrobial peptides from the skin of brown frog, Rana zhenhaiensis. | Zoolog Sci | 2012
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis