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Peptide record

TPDB11699

Antibacterial Antifungal Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11699
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIFSLIKTAAKFVGKNLLKQAGKAGLEHLACKANNQC
Physicochemical Analysis
C173H290N50O47S2
RDMPWY
AK
3886.63
10.27
7
1
16
+5
4.54
0.078
97.84
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.22
9
Residue Composition
number
6
A
0
R
3
N
0
D
2
C
1
E
2
Q
4
G
1
H
2
I
5
L
6
K
0
M
2
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 6 R: 0 N: 3 D: 0 C: 2 E: 1 Q: 2 G: 4 H: 1 I: 2 L: 5 K: 6 M: 0 F: 2 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
37
C173H290N50O47S2
3886.63
10.27
+5
4.54
0.078
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

E. faecium 091299

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGM
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGMCC 1.50 (MIC 100 uM), K. Pneum
Evidence 4 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

us ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGMCC 1.50 (MIC 100 uM), K. Pneumoniae 08040724 (MIC 50 uM), E. cloa
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µM

Target

K. Pneumoniae 08040724

Source & Reference

dbAMP

Other

12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGMCC 1.50 (MIC 100 uM), K. Pneumoniae 08040724 (MIC 50 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

1.50 (MIC 100 uM), K. Pneumoniae 08040724 (MIC 50 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C. glabrata 090902 (MIC 100 uM), C.albicans(ATCC
Evidence 7 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

P. faecalis X29

Source & Reference

dbAMP

Other

08040724 (MIC 50 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C. glabrata 090902 (MIC 100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
100 µM

Target

C. glabrata 090902

Source & Reference

dbAMP

Other

1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C. glabrata 090902 (MIC 100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µM

Target

E. faecium 091299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGM
Evidence 11 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGMCC 1.50 (MIC 100 uM), K. Pneum
Evidence 12 Activity

Activity

MIC
Antifungal
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC12.5 uM), E. faecalis 981 (MIC12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGMCC 1.50 (MIC 100 uM), K. Pneumoniae 08040724 (MIC 50 uM), E. cloa
Evidence 13 Activity

Activity

MIC
Antifungal
50 µM

Target

K. Pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

12.5 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P. aeruginosa CGMCC 1.50 (MIC 100 uM), K. Pneumoniae 08040724 (MIC 50 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.50 (MIC 100 uM), K. Pneumoniae 08040724 (MIC 50 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C. glabrata 090902 (MIC 100 uM), C.albicans(ATCC
Evidence 15 Activity

Activity

MIC
Antifungal
3.1 µM

Target

P. faecalis X29

Source & Reference

dbAMP CAFPdb Antifungipept

Other

08040724 (MIC 50 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C. glabrata 090902 (MIC 100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
100 µM

Target

C. glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C. glabrata 090902 (MIC 100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 18 Activity

Activity

1% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
1% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 19 Activity

Activity

10% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
10% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 20 Activity

Activity

12% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
12% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 21 Activity

Activity

24% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
24% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 22 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.