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Peptide record

TPDB11686

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

37 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11686

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLMSVTKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC

FASTA

>TPDB11686|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=37
GLMSVTKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC

Formula C166H286N48O48S3

Absent Amino Acids REPWY

Common Amino Acids GK

Mass 3818.57

PI 10.27

Basic Residues 7

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +5

Boman Index 5.61

Hydrophobicity 0.089

Aliphatic Index 92.16

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.27

Polar Residues 10

number

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 1 C: 2 E: 0 Q: 2 G: 6 H: 1 I: 2 L: 4 K: 6 M: 1 F: 1 P: 0 S: 3 T: 2 W: 0 Y: 0 V: 3

Length

Formula

C166H286N48O48S3

Mass

3818.57

10.27

Net Charge

Boman Index

5.61

Hydrophobicity

0.089

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/202

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

i (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (M

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/202

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

i (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (M

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/202

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

i (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (M

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/202

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

i (MIC 3 uM), P. aeruginosa (MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 6 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 12 uM), S. aureus (MIC 25 uM), and C. albicans (MIC 100 uM). HC50 125 uM. Updated 11/2019 7/2021

Evidence 25 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 125 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. | Regul Pept | 2004

Evidence 26 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.