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Peptide record

TPDB11678

Antibacterial Antifungal Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11678
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
SSRRPCRGRSCGPRLRGGYTLIGRPVKNQNRPKYMWV
Physicochemical Analysis
C184H305N67O47S3
ADEHF
R
4304.05
12.19
10
0
9
+10
6.53
-1.132
47.30
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
8605
199.93
11
Residue Composition
number
0
A
8
R
2
N
0
D
2
C
0
E
1
Q
5
G
0
H
1
I
2
L
2
K
1
M
0
F
4
P
3
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 8 N: 2 D: 0 C: 2 E: 0 Q: 1 G: 5 H: 0 I: 1 L: 2 K: 2 M: 1 F: 0 P: 4 S: 3 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
37
C184H305N67O47S3
4304.05
12.19
+10
6.53
-1.132
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
40 µg/mL

Target

A. hydrophila

Source & Reference

NA

Other

active against habitat bacteria A. hydrophila (MIC 40 ug/ml), V. splendidus (MIC 6.25 ug/ml), and S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

V. splendidus

Source & Reference

NA

Other

active against habitat bacteria A. hydrophila (MIC 40 ug/ml), V. splendidus (MIC 6.25 ug/ml), and S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC 25922, P.aeruginosa ATCC 27853,
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

S. iniae

Source & Reference

NA

Other

gainst habitat bacteria A. hydrophila (MIC 40 ug/ml), V. splendidus (MIC 6.25 ug/ml), and S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC 25922, P.aeruginosa ATCC 27853, and S.aureus ATCC 25923 (MIC >
Evidence 4 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

S.aureus ATCC 25923

Source & Reference

NA

Other

S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC 25922, P.aeruginosa ATCC 27853, and S.aureus ATCC 25923 (MIC >200 ug/ml). An alternative cleaved form of the peptide is BG-CATH(5-37), which lacks the N-terminal
Evidence 5 Activity

Activity

MIC
Antifungal
40 µg/mL

Target

A. hydrophila

Source & Reference

Antifungipept

Other

active against habitat bacteria A. hydrophila (MIC 40 ug/ml), V. splendidus (MIC 6.25 ug/ml), and S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

V. splendidus

Source & Reference

Antifungipept

Other

active against habitat bacteria A. hydrophila (MIC 40 ug/ml), V. splendidus (MIC 6.25 ug/ml), and S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC 25922, P.aeruginosa ATCC 27853,
Evidence 7 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

S. iniae

Source & Reference

Antifungipept

Other

gainst habitat bacteria A. hydrophila (MIC 40 ug/ml), V. splendidus (MIC 6.25 ug/ml), and S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC 25922, P.aeruginosa ATCC 27853, and S.aureus ATCC 25923 (MIC >
Evidence 8 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

S.aureus ATCC 25923

Source & Reference

Antifungipept

Other

S. iniae (MIC 12.5 ug/ml), but inactive: E.coli ATCC 25922, P.aeruginosa ATCC 27853, and S.aureus ATCC 25923 (MIC >200 ug/ml). An alternative cleaved form of the peptide is BG-CATH(5-37), which lacks the N-terminal
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel cathelicidin from Bufo bufo gargarizans Cantor showed specific activity to its habitat bacteria. | Gene | 2015