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Peptide record

TPDB11675

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11675
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GFGCPFNARRCHRHCRSIRRRAGYCAGRLRLTCTCVR
Physicochemical Analysis
C177H294N72O43S6
DEQKMW
R
4311.10
11.81
12
0
10
+10
4.83
-0.522
47.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
43.26
11
Residue Composition
number
3
A
10
R
1
N
0
D
6
C
0
E
0
Q
4
G
2
H
1
I
2
L
0
K
0
M
2
F
1
P
1
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 10 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 4 H: 2 I: 1 L: 2 K: 0 M: 0 F: 2 P: 1 S: 1 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C177H294N72O43S6
4311.10
11.81
+10
4.83
-0.522
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus CNCC63202

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
MIC90 recorded here: Active against Gram+ bacteria S. aureus CNCC63202 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

M. luteus CMCC28001

Source & Reference

dbAMP

Other

MIC90 recorded here: Active against Gram+ bacteria S. aureus CNCC63202 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 29
Evidence 3 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

M. bovis

Source & Reference

dbAMP

Other

against Gram+ bacteria S. aureus CNCC63202 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 297-GFP(MIC 50 uM) as wel
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli CMCC44103

Source & Reference

dbAMP

Other

02 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 297-GFP(MIC 50 uM) as well as fungi C-albicans CAU0037 (MIC >50 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µM

Target

B. burgdorferi 297-GFP

Source & Reference

dbAMP

Other

28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 297-GFP(MIC 50 uM) as well as fungi C-albicans CAU0037 (MIC >50 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus CNCC63202

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
MIC90 recorded here: Active against Gram+ bacteria S. aureus CNCC63202 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

M. luteus CMCC28001

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC90 recorded here: Active against Gram+ bacteria S. aureus CNCC63202 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 29
Evidence 8 Activity

Activity

MIC
Antifungal
0.5 µM

Target

M. bovis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

against Gram+ bacteria S. aureus CNCC63202 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 297-GFP(MIC 50 uM) as wel
Evidence 9 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli CMCC44103

Source & Reference

dbAMP CAFPdb Antifungipept

Other

02 (MIC 50 uM) M. luteus CMCC28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 297-GFP(MIC 50 uM) as well as fungi C-albicans CAU0037 (MIC >50 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
50 µM

Target

B. burgdorferi 297-GFP

Source & Reference

dbAMP CAFPdb Antifungipept

Other

28001 (MIC 10 uM) M. bovis (MIC 0.5 uM) and Gram- bacteria E. coli CMCC44103 (MIC 5 uM) B. burgdorferi 297-GFP(MIC 50 uM) as well as fungi C-albicans CAU0037 (MIC >50 uM).
Evidence 11 Activity

Activity

<5% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
<5% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 12 Activity

Activity

18% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
18% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 13 Activity

Activity

60% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
60% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 14 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 15 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=10µM 18% Hemolysis=20µM 60% Hemolysis=50µM | Cytotoxicity: HEK293T: Not active up to 20 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Parasit Vectors. 2017 Oct 2 10(1):455.
Evidence 16 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.