Back to search

Peptide record

TPDB11665

Antibacterial Antifungal Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11665
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RAAPQRRLRAMARLKKFAEAGGADPDSGGLRARFPER
Physicochemical Analysis
C174H292N64O48S1
NCHITWYV
AR
4080.69
12.19
10
4
14
+6
11.53
-0.951
53.24
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
8
A
8
R
0
N
2
D
0
C
2
E
1
Q
4
G
0
H
0
I
3
L
2
K
1
M
2
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 8 N: 0 D: 2 C: 0 E: 2 Q: 1 G: 4 H: 0 I: 0 L: 3 K: 2 M: 1 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
37
C174H292N64O48S1
4080.69
12.19
+6
11.53
-0.951
Evidence Records 4 records
Evidence 1 Activity

Activity

7.14% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
7.14% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 2 Activity

Activity

9.62% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
9.62% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 3 Activity

Activity

6.47% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
6.47% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 4 Activity

Activity

16.29% Degranulation
Toxicity
100 µg/mL
Cytotoxic
16.29% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018