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Peptide record

TPDB11665

Antibacterial Antifungal Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11665
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 37-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RAAPQRRLRAMARLKKFAEAGGADPDSGGLRARFPER
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C174H292N64O48S1
NCHITWYV
AR
4080.69
12.19
10
4
14
+6
3.49
-0.951
53.24
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
8
A
8
R
0
N
2
D
0
C
2
E
1
Q
4
G
0
H
0
I
3
L
2
K
1
M
2
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 8 N: 0 D: 2 C: 0 E: 2 Q: 1 G: 4 H: 0 I: 0 L: 3 K: 2 M: 1 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
37 reviewed residue count
C174H292N64O48S1 sequence-only estimate (linear, free termini)
4080.69 sequence-only estimate (linear, free termini)
12.19 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
3.49 sequence-only estimate (linear, free termini)
-0.951 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

7.14% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
7.14% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 2 Activity

Activity

9.62% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
9.62% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 3 Activity

Activity

6.47% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
6.47% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 4 Activity

Activity

16.29% Degranulation
Toxicity
100 µg/mL
Cytotoxic
16.29% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018