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Peptide record

TPDB11660

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11660
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GYGCPFNQYQCHSHCSGIRGYKGGYCKGTFKQTCKCY
Physicochemical Analysis
C181H262N52O51S6
ADELMWV
G
4174.75
8.82
7
0
8
+5
1.20
-0.792
10.54
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7825
187.44
19
Residue Composition
number
0
A
1
R
1
N
0
D
6
C
0
E
3
Q
7
G
2
H
1
I
0
L
4
K
0
M
2
F
1
P
2
S
2
T
0
W
5
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 6 E: 0 Q: 3 G: 7 H: 2 I: 1 L: 0 K: 4 M: 0 F: 2 P: 1 S: 2 T: 2 W: 0 Y: 5 V: 0
Chemical Descriptors
37
C181H262N52O51S6
4174.75
8.82
+5
1.20
-0.792
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity and mechanism of action of tick defensin against Gram-positive bacteria. | Biochim Biophys Acta | 2003
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity and mechanism of action of tick defensin against Gram-positive bacteria. | Biochim Biophys Acta | 2003
Evidence 3 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.