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Peptide record

TPDB11657

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11657
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifp Antifungipept
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKFSGFAKILKSIAKFFKGVGKVRKQFKEASDLDKNQ
Physicochemical Analysis
C192H310N52O50
CHMPTWY
K
4146.89
10.81
10
3
14
+7
8.45
-0.546
65.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
3
A
1
R
1
N
2
D
0
C
1
E
2
Q
4
G
0
H
2
I
2
L
9
K
0
M
5
F
0
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 2 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 2 L: 2 K: 9 M: 0 F: 5 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C192H310N52O50
4146.89
10.81
+7
8.45
-0.546
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
6.2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
6.2 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Oxki2 is active against S. aureus (MIC 6.2 uM) and E. coli (MIC 12.5 uM).
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11976325]10% hemolytic activity at 50 µM against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2002 Jun 28 277(26):23627-23637.