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Peptide record

TPDB11649

Antibacterial Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB11649
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 37-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILDTLKQFAKGVGKWLVKGAAQGVLSTVSCKLAKTC
Physicochemical Analysis
C172H292N46O47S2
RNEHMPY
K
3820.61
10.27
6
1
16
+5
2.09
0.400
105.41
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
147.23
9
Residue Composition
number
4
A
0
R
0
N
1
D
2
C
0
E
2
Q
5
G
0
H
1
I
5
L
6
K
0
M
1
F
0
P
2
S
3
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 2 G: 5 H: 0 I: 1 L: 5 K: 6 M: 0 F: 1 P: 0 S: 2 T: 3 W: 1 Y: 0 V: 4
Chemical Descriptors
37
C172H292N46O47S2
3820.61
10.27
+5
2.09
0.400
Evidence Records 3 records
Evidence 1 Activity

Activity

1.97% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
1.97% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4. | Eur J Biochem | 2002
Evidence 2 Activity

Activity

52.9% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
52.9% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4. | Eur J Biochem | 2002
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.12199716] 1.97% hemolytic activity at 10 µg/mL, 52.9% hemolytic activity at 100 µg/mL against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2002 Sep 269(17):4367-4374.