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Peptide record

TPDB11640

Antibacterial Antifungal Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB11640
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KRGLWESLKRKVTKLGDDIRNTLRNFKIKFPVPRQG
Physicochemical Analysis
C194H325N61O49
ACHMY
K
4296.09
11.91
11
3
11
+8
10.40
-1.006
81.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
128.02
6
Residue Composition
number
0
A
5
R
2
N
2
D
0
C
1
E
1
Q
3
G
0
H
2
I
4
L
6
K
0
M
2
F
2
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 2 D: 2 C: 0 E: 1 Q: 1 G: 3 H: 0 I: 2 L: 4 K: 6 M: 0 F: 2 P: 2 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
36
C194H325N61O49
4296.09
11.91
+8
10.40
-1.006
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-14 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (MIC 4-14 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
4-14 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (MIC 4-14 uM).
Evidence 3 Activity

Activity

41% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
41% Hemolysis | 50 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Marsupial and Monotreme Cathelicidins Display Antimicrobial Activity, Including Against Methicillin-Resistant Staphylococcus Aureus | Microbiology | 2017
Evidence 4 Activity

Activity

3.9% Killing
Toxicity
50 µM
Cytotoxic
3.9% Killing | 50 | µM | target cell: Madin-Darby bovine kidney cells

Target

Madin-Darby bovine kidney cells

Source & Reference

NA
DBAASP
Marsupial and Monotreme Cathelicidins Display Antimicrobial Activity, Including Against Methicillin-Resistant Staphylococcus Aureus | Microbiology | 2017