Back to search

Peptide record

TPDB11634

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11634
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SIGTAVKKAVPIAKKVGKVAIPIAKAVLSVVGQLVG
Physicochemical Analysis
C163H293N43O41
RNDCEHMFWY
V
3511.38
11.21
6
0
20
+6
5.04
1.000
146.11
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
4
I
2
L
6
K
0
M
0
F
2
P
2
S
1
T
0
W
0
Y
8
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 4 L: 2 K: 6 M: 0 F: 0 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 8
Chemical Descriptors
36
C163H293N43O41
3511.38
11.21
+6
5.04
1.000
Evidence Records 4 records
Evidence 1 Activity

Activity

Hemolysis
[Swiss_Prot Entry O17513]has hemolytic activity

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Insect Biochem Mol Biol. 1997 Dec 27(12):1039-1046.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

100% Hemolysis
Toxicity
84 µM
Hemolytic Cytotoxic
100% Hemolysis | 84 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity and pore-forming properties of ceratotoxins: a mechanism of action based on the barrel stave model. | Biochim Biophys Acta | 2004
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Swiss_Prot Entry O17513]has hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
Insect Biochem Mol Biol. 1997 Dec 27(12):1039-1046.
Evidence 4 Hemolysis

Activity

[Swiss_Prot Entry O17513]has hemolytic activity
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Insect Biochem Mol Biol. 1997 Dec 27(12):1039-1046.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.