TPDB

3D PDB MODEL

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TPDB ID TPDB11629

Peptide_Name

hBD-1

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP AVPpred-BWR DRAVP 2.0 BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK

FASTA

>TPDB11629|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Blood-Brain Barrier;Toxicity|length=36
DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK

Formula C167H262N48O50S6

Absent Amino Acids EMW

Common Amino Acids C

Mass 3934.57

PI 8.57

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +4

Boman Index 2.86

Hydrophobicity -0.272

Aliphatic Index 46.11

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 4845

Absorbance 280nm 123.14

Polar Residues 17

number

2

A

1

R

1

N

1

D

6

C

0

E

2

Q

4

G

1

H

2

I

1

L

4

K

0

M

1

F

1

P

3

S

2

T

0

W

3

Y

1

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 2 G: 4 H: 1 I: 2 L: 1 K: 4 M: 0 F: 1 P: 1 S: 3 T: 2 W: 0 Y: 3 V: 1

Length

36

Formula

C167H262N48O50S6

Mass

3934.57

PI

8.57

Net Charge

+4

Boman Index

2.86

Hydrophobicity

-0.272

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Antibacterial

Origin

keratinocytes skin platelets Homo sapiens

Evidence 1 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Fibrosarcoma

Cell Line Not Available

Tissue Affected Fibrous connective tissue

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1995

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint 21.62% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

21.62% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Activity of human beta defensin-1 and its motif against active and dormant Mycobacterium tuberculosis. | Appl Microbiol Biotechnol | 2017