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Peptide record

TPDB11627

Antibacterial Antifungal Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11627
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DHYLCVKNEGICLYSSCPSYTKIEGTCYGGKAKCCK
Physicochemical Analysis
C170H266N44O53S6
RQMFW
C
3966.61
8.01
6
3
10
+2
5.72
-0.314
54.17
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
6335
159.71
16
Residue Composition
number
1
A
0
R
1
N
1
D
6
C
2
E
0
Q
4
G
1
H
2
I
2
L
5
K
0
M
0
F
1
P
3
S
2
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 6 E: 2 Q: 0 G: 4 H: 1 I: 2 L: 2 K: 5 M: 0 F: 0 P: 1 S: 3 T: 2 W: 0 Y: 4 V: 1
Chemical Descriptors
36
C170H266N44O53S6
3966.61
8.01
+2
5.72
-0.314
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.5 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans AT
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

Staphylococcus aureus ATCC 43300

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-
Evidence 3 Activity

Activity

MIC
Antibacterial
18 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01
Evidence 4 Activity

Activity

MIC
Antibacterial
24 µg/mL

Target

Candida albicans ATCC 20032

Source & Reference

dbAMP

Other

MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC
Evidence 5 Activity

Activity

MIC
Antibacterial
24 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP

Other

IC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC 27853 (MIC 12 ug/ml). Updated 5
Evidence 6 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Pseudomonas aeruginosa PA01

Source & Reference

dbAMP

Other

633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC 27853 (MIC 12 ug/ml). Updated 5/2017 7/2021.
Evidence 7 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

0032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC 27853 (MIC 12 ug/ml). Updated 5/2017 7/2021.
Evidence 8 Activity

Activity

MIC
Antifungal
4.5 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans AT
Evidence 9 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

Staphylococcus aureus ATCC 43300

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-
Evidence 10 Activity

Activity

MIC
Antifungal
18 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01
Evidence 11 Activity

Activity

MIC
Antifungal
24 µg/mL

Target

Candida albicans ATCC 20032

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 4.5 ug/ml), S. aureus ATCC 43300 (MIC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC
Evidence 12 Activity

Activity

MIC
Antifungal
24 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 3 ug/ml), B. subtilis ATCC 6633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC 27853 (MIC 12 ug/ml). Updated 5
Evidence 13 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Pseudomonas aeruginosa PA01

Source & Reference

dbAMP CAFPdb Antifungipept

Other

633 (MIC 18 ug/ml), C. albicans ATCC 20032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC 27853 (MIC 12 ug/ml). Updated 5/2017 7/2021.
Evidence 14 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0032 (MIC 24 ug/ml), E. coli ML-35P (MIC 24 ug/ml), P. aeruginosa PA01 (MIC 12 ug/ml) and P. aeruginosa ATCC 27853 (MIC 12 ug/ml). Updated 5/2017 7/2021.
Evidence 15 Activity

Activity

2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri. | Gene | 2012
Evidence 16 Activity

Activity

2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri. | Gene | 2012