TPDB11624

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.47 µM

Target

Target Organism Escherichia coli DH5alpha

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.14 µM

Target

Target Organism S. enterica ATCC 14028

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.47-1.90 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 and 14 clinical isolates

Source & Reference

Database Source dbAMP

Other

Evidence Text

ctive against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isola

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.95-1.90 µM

Target

Target Organism A. baumannii ATCC 19606 and 3 clinical isolates

Source & Reference

Database Source dbAMP

Other

Evidence Text

and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM),

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.47-7.59 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883 and 3 clinical isolates

Source & Reference

Database Source dbAMP

Other

Evidence Text

, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.50 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP

Other

Evidence Text

rain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.01 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Evidence Text

e ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATC

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.66 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMI

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.22 µM

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.30 µM

Target

Target Organism Candida albicans ATCC 753

Source & Reference

Database Source dbAMP

Other

Evidence Text

3 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.47 µM

Target

Target Organism Escherichia coli DH5alpha

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.14 µM

Target

Target Organism S. enterica ATCC 14028

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.47-1.90 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 and 14 clinical isolates

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ctive against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isola

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.95-1.90 µM

Target

Target Organism A. baumannii ATCC 19606 and 3 clinical isolates

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM),

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.47-7.59 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883 and 3 clinical isolates

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.50 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

rain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.01 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

e ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATC

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.66 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMI

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.22 µM

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.30 µM

Target

Target Organism Candida albicans ATCC 753

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

3 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.47 µM

Target

Target Organism Escherichia coli DH5alpha

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.14 µM

Target

Target Organism S. enterica ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.47-1.90 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 and 14 clinical isolates

Source & Reference

Database Source NA

Other

Evidence Text

ctive against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isola

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.95-1.90 µM

Target

Target Organism A. baumannii ATCC 19606 and 3 clinical isolates

Source & Reference

Database Source NA

Other

Evidence Text

and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM),

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.47-7.59 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883 and 3 clinical isolates

Source & Reference

Database Source NA

Other

Evidence Text

, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.50 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

rain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.01 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

e ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATC

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.66 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMI

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.22 µM

Target

Target Organism S. uberis

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.30 µM

Target

Target Organism Candida albicans ATCC 753

Source & Reference

Database Source NA

Other

Evidence Text

3 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.47 µM

Target

Target Organism Escherichia coli DH5alpha

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.14 µM

Target

Target Organism S. enterica ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.47-1.90 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 and 14 clinical isolates

Source & Reference

Database Source NA

Other

Evidence Text

ctive against Gram- E. coli DH5alpha (MIC 0.47 uM), S. enterica ATCC 14028 (MIC 1.14 uM), P. aeruginosa ATCC 27853 and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isola

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.95-1.90 µM

Target

Target Organism A. baumannii ATCC 19606 and 3 clinical isolates

Source & Reference

Database Source NA

Other

Evidence Text

and 14 clinical isolates (MIC 0.47-1.90 uM) three strains (MIC>30.4 uM), AMP-resistant?, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM),

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.47-7.59 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883 and 3 clinical isolates

Source & Reference

Database Source NA

Other

Evidence Text

, A. baumannii ATCC 19606 and 3 clinical isolates (MIC 0.95-1.90 uM) one strain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.50 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

rain >15.2 uM, K. pneumoniae ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.01 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

e ATCC 13883 and 3 clinical isolates (MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATC

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.66 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 0.47-7.59 uM), Gram+ B. subtilis (MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMI

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.22 µM

Target

Target Organism S. uberis

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 1.50 uM), S. aureus ATCC 25923 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.30 µM

Target

Target Organism Candida albicans ATCC 753

Source & Reference

Database Source NA

Other

Evidence Text

3 (MIC 1.01 uM), S. pyogenes ATCC 19615 (MIC 0.66 uM), S. uberis (MIC 1.22 uM), and fungi C. albicans ATCC 753 (MIC 1.30 uM). Bactericidal 2xMIC killed in 10 min.