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Peptide record

TPDB11619

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB11619
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGCG
Physicochemical Analysis
C191H336N62O39S1
ANDEQHMY
K
4157.22
12.72
13
0
12
+13
6.90
-0.461
102.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
132.30
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
0
Q
5
G
0
H
4
I
4
L
7
K
0
M
1
F
3
P
1
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 5 H: 0 I: 4 L: 4 K: 7 M: 0 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
36
C191H336N62O39S1
4157.22
12.72
+13
6.90
-0.461
Evidence Records 6 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
5% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida. | Sci Rep | 2016
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA. | FEBS Lett | 1994
Evidence 3 Activity

Activity

9% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
9% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues. | Microb Pathog | 2019
Evidence 4 Activity

Activity

25% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
25% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues. | Microb Pathog | 2019
Evidence 5 Activity

Activity

LC50
Toxicity
>512 µg/mL
Cytotoxic
LC50 | >512 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues. | Microb Pathog | 2019
Evidence 6 Activity

Activity

MHC
Toxicity
4 µM
Hemolytic
Hemolytic_activity: [Ref.27251456] 5% hemolysis at 4 µM, MHC=4 µM against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2016 Jun 2 6:27258.