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Peptide record

TPDB11618

DLP-PH Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11618
DLP-PH
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
NLVSALIEGRKYLKNVLKKLNRLKEKNKAKNSKENN
Physicochemical Analysis
C184H324N58O53
DCQHMFPTW
K
4196.95
10.84
11
3
12
+8
14.99
-1.197
97.50
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1490
35.50
10
Residue Composition
number
2
A
2
R
7
N
0
D
0
C
3
E
0
Q
1
G
0
H
1
I
6
L
9
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 7 D: 0 C: 0 E: 3 Q: 0 G: 1 H: 0 I: 1 L: 6 K: 9 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
36
C184H324N58O53
4196.95
10.84
+8
14.99
-1.197
Free
L
Linear
Free
Antimicrobial
Phyllomedusa hypochondrialis
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 ug/mL

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits prolife
Evidence 2 Activity

Activity

MIC
Antibacterial
64 ug/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits proliferation of cancer cell lines su
Evidence 3 Activity

Activity

MIC
Antibacterial
64 ug/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

inst bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits proliferation of cancer cell lines such as H157, and PC3, but with little
Evidence 4 Activity

Activity

IC50
IC50 = 15.41 µg/mL
Anticancer
15.41 µg/mL

Target

Lung Cancer
H-157
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

IC50
IC50 = 32.25 µg/mL
Anticancer
32.25 µg/mL

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018
Evidence 6 Activity

Activity

MIC
Antifungal
32 ug/mL

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits prolife
Evidence 7 Activity

Activity

MIC
Antifungal
64 ug/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits proliferation of cancer cell lines su
Evidence 8 Activity

Activity

MIC
Antifungal
64 ug/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

inst bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits proliferation of cancer cell lines such as H157, and PC3, but with little
Evidence 9 Activity

Activity

MIC
Antiparasitic
32 ug/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits prolife
Evidence 10 Activity

Activity

MIC
Antiparasitic
64 ug/mL

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits proliferation of cancer cell lines su
Evidence 11 Activity

Activity

MIC
Antiparasitic
64 ug/mL

Target

Candida albicans

Source & Reference

NA

Other

inst bacteria mainly Gram- E. coli (MIC 32 ug/mL), P. aeruginosa (MIC 64 ug/mL) and fungi C. albicans (MIC 64 ug/mL). Also inhibits proliferation of cancer cell lines such as H157, and PC3, but with little
Evidence 12 Activity

Activity

IC50
Toxicity
287.2 µg/mL
Cytotoxic
IC50 | 287.2 | µg/mL | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018
Evidence 13 Activity

Activity

20% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018
Evidence 14 Activity

Activity

35% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
35% Hemolysis | 128 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018
Evidence 15 Activity

Activity

45% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 256 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018
Evidence 16 Activity

Activity

60% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
60% Hemolysis | 512 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018
Evidence 17 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.