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Peptide record

TPDB11614

Antibacterial Anticancer Antifungal Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11614
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KKPSKKPKPQAMTFPKVTVEYFPASFSTAALTVPED
Physicochemical Analysis
C184H289N43O52S1
RNCGHIW
KP
3967.64
10.11
6
3
13
+3
9.85
-0.544
46.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
37.55
9
Residue Composition
number
4
A
0
R
0
N
1
D
0
C
2
E
1
Q
0
G
0
H
0
I
1
L
6
K
1
M
3
F
6
P
3
S
4
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 6 M: 1 F: 3 P: 6 S: 3 T: 4 W: 0 Y: 1 V: 3
Chemical Descriptors
36
C184H289N43O52S1
3967.64
10.11
+3
9.85
-0.544
Evidence Records 46 records
Evidence 1 Activity

Activity

MIC
Antibacterial
18.75-37.5 µg/mL

Target

Escherichia coli ATCC25922 or IS series

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli ATCC25922 or IS series (MIC 18.75-37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca
Evidence 2 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

D.bacillus IS

Source & Reference

dbAMP

Other

Active against Gram- E. coli ATCC25922 or IS series (MIC 18.75-37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (M
Evidence 3 Activity

Activity

MIC
Antibacterial
37.5-75 µg/mL

Target

Klebsiella pneumoniae IS sereis

Source & Reference

dbAMP

Other

m- E. coli ATCC25922 or IS series (MIC 18.75-37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/m
Evidence 4 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

Klebsiella oxytoca IS

Source & Reference

dbAMP

Other

37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml
Evidence 5 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

P.vulgaris

Source & Reference

dbAMP

Other

C >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

P.mirabilis IS

Source & Reference

dbAMP

Other

IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090
Evidence 7 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

A.baumannii

Source & Reference

dbAMP

Other

oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aerug
Evidence 8 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

Stenotrophomonas maltophilia IS 7404

Source & Reference

dbAMP

Other

.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aeruginosa ATCC 27853 IS 1411 (MIC >200 ug/m
Evidence 9 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

S.maltophilia IS 090223

Source & Reference

dbAMP

Other

IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aeruginosa ATCC 27853 IS 1411 (MIC >200 ug/ml), P. aeruginosa (IS 08031014) (MIC 37.5
Evidence 10 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

P.aeruginosa ATCC 27853 IS 1411

Source & Reference

dbAMP

Other

ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aeruginosa ATCC 27853 IS 1411 (MIC >200 ug/ml), P. aeruginosa (IS 08031014) (MIC 37.5 ug/ml), S.paratyphi (IS) (MIC >200 uM), Gram+ S. a
Evidence 11 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

Staphylococcus aureus IS1307

Source & Reference

dbAMP

Other

S) (MIC >200 uM), Gram+ S. aureus ATCC25922, IS 1303, IS 08032XXX series (MIC>200 ug/ml), S. aureus IS1307 (MIC 75 ug/ml), B.cereus, B.subtilis IS (MIC >200 ug/ml), E.faecium (IS 1299) (MIC >200 ug/ml), N.astero
Evidence 12 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

B.subtilis IS

Source & Reference

dbAMP

Other

, IS 1303, IS 08032XXX series (MIC>200 ug/ml), S. aureus IS1307 (MIC 75 ug/ml), B.cereus, B.subtilis IS (MIC >200 ug/ml), E.faecium (IS 1299) (MIC >200 ug/ml), N.asteroids (IS) (MIC >200 ug/ml), E.faecalis IS98
Evidence 13 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

Enterococcus faecalis IS981

Source & Reference

dbAMP

Other

MIC >200 ug/ml), E.faecium (IS 1299) (MIC >200 ug/ml), N.asteroids (IS) (MIC >200 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S.epidermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug
Evidence 14 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

S.epidermidis

Source & Reference

dbAMP

Other

) (MIC >200 ug/ml), N.asteroids (IS) (MIC >200 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S.epidermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MI
Evidence 15 Activity

Activity

MIC
Antibacterial
37.5-75 µg/mL

Target

Candida albicans IS 8022821 or 08030809

Source & Reference

dbAMP

Other

MIC >200 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S.epidermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802
Evidence 16 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

C.albicans IS 08022821

Source & Reference

dbAMP

Other

idermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802 (MIC >200 ug/ml), aquatic pathogenic ba
Evidence 17 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

A.cinerea

Source & Reference

dbAMP

Other

icans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802 (MIC >200 ug/ml), aquatic pathogenic bacteria V.harveyi, V.parahaem
Evidence 18 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

C.glabrata IS 08A802

Source & Reference

dbAMP

Other

(MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802 (MIC >200 ug/ml), aquatic pathogenic bacteria V.harveyi, V.parahaemolyticus, V.brasiliensis, V.cholerae (M
Evidence 19 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

V.cholerae

Source & Reference

dbAMP

Other

C >200 ug/ml), aquatic pathogenic bacteria V.harveyi, V.parahaemolyticus, V.brasiliensis, V.cholerae (MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >2
Evidence 20 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

E.tarda

Source & Reference

dbAMP

Other

enic bacteria V.harveyi, V.parahaemolyticus, V.brasiliensis, V.cholerae (MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >200 ug/ml). Validated 7/202
Evidence 21 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

A.hydrophila

Source & Reference

dbAMP

Other

lyticus, V.brasiliensis, V.cholerae (MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >200 ug/ml). Validated 7/2021 formatted 8/2024
Evidence 22 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

A.veronii

Source & Reference

dbAMP

Other

(MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >200 ug/ml). Validated 7/2021 formatted 8/2024
Evidence 23 Activity

Activity

MIC
Antifungal
18.75-37.5 µg/mL

Target

Escherichia coli ATCC25922 or IS series

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli ATCC25922 or IS series (MIC 18.75-37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca
Evidence 24 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

D.bacillus IS

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli ATCC25922 or IS series (MIC 18.75-37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (M
Evidence 25 Activity

Activity

MIC
Antifungal
37.5-75 µg/mL

Target

Klebsiella pneumoniae IS sereis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

m- E. coli ATCC25922 or IS series (MIC 18.75-37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/m
Evidence 26 Activity

Activity

MIC
Antifungal
75 µg/mL

Target

Klebsiella oxytoca IS

Source & Reference

dbAMP CAFPdb Antifungipept

Other

37.5 ug/ml), D.bacillus IS (MIC >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml
Evidence 27 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

P.vulgaris

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C >200 ug/ml), K. pneumoniae IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MI
Evidence 28 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

P.mirabilis IS

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IS sereis (MIC 37.5-75 ug/ml), K. oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090
Evidence 29 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

A.baumannii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

oxytoca IS (MIC 75 ug/ml), P.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aerug
Evidence 30 Activity

Activity

MIC
Antifungal
75 µg/mL

Target

Stenotrophomonas maltophilia IS 7404

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.vulgaris (MIC >200 ug/ml), P.mirabilis IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aeruginosa ATCC 27853 IS 1411 (MIC >200 ug/m
Evidence 31 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

S.maltophilia IS 090223

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IS (MIC >200 ug/ml), A.baumannii (MIC>200 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aeruginosa ATCC 27853 IS 1411 (MIC >200 ug/ml), P. aeruginosa (IS 08031014) (MIC 37.5
Evidence 32 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

P.aeruginosa ATCC 27853 IS 1411

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S.maltophilia IS 090223 (MIC >200 ug/ml), P.aeruginosa ATCC 27853 IS 1411 (MIC >200 ug/ml), P. aeruginosa (IS 08031014) (MIC 37.5 ug/ml), S.paratyphi (IS) (MIC >200 uM), Gram+ S. a
Evidence 33 Activity

Activity

MIC
Antifungal
75 µg/mL

Target

Staphylococcus aureus IS1307

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S) (MIC >200 uM), Gram+ S. aureus ATCC25922, IS 1303, IS 08032XXX series (MIC>200 ug/ml), S. aureus IS1307 (MIC 75 ug/ml), B.cereus, B.subtilis IS (MIC >200 ug/ml), E.faecium (IS 1299) (MIC >200 ug/ml), N.astero
Evidence 34 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

B.subtilis IS

Source & Reference

dbAMP CAFPdb Antifungipept

Other

, IS 1303, IS 08032XXX series (MIC>200 ug/ml), S. aureus IS1307 (MIC 75 ug/ml), B.cereus, B.subtilis IS (MIC >200 ug/ml), E.faecium (IS 1299) (MIC >200 ug/ml), N.asteroids (IS) (MIC >200 ug/ml), E.faecalis IS98
Evidence 35 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

Enterococcus faecalis IS981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC >200 ug/ml), E.faecium (IS 1299) (MIC >200 ug/ml), N.asteroids (IS) (MIC >200 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S.epidermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug
Evidence 36 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

S.epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

) (MIC >200 ug/ml), N.asteroids (IS) (MIC >200 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S.epidermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MI
Evidence 37 Activity

Activity

MIC
Antifungal
37.5-75 µg/mL

Target

Candida albicans IS 8022821 or 08030809

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC >200 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S.epidermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802
Evidence 38 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

C.albicans IS 08022821

Source & Reference

dbAMP CAFPdb Antifungipept

Other

idermidis (MIC >200 ug/ml), fungi C. albicans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802 (MIC >200 ug/ml), aquatic pathogenic ba
Evidence 39 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

A.cinerea

Source & Reference

dbAMP CAFPdb Antifungipept

Other

icans IS 8022821 or 08030809 (MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802 (MIC >200 ug/ml), aquatic pathogenic bacteria V.harveyi, V.parahaem
Evidence 40 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

C.glabrata IS 08A802

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 37.5-75 ug/ml), C.albicans IS 08022821 (MIC>200 ug/ml), A.cinerea (MIC >200 ug/ml), C.glabrata IS 08A802 (MIC >200 ug/ml), aquatic pathogenic bacteria V.harveyi, V.parahaemolyticus, V.brasiliensis, V.cholerae (M
Evidence 41 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

V.cholerae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C >200 ug/ml), aquatic pathogenic bacteria V.harveyi, V.parahaemolyticus, V.brasiliensis, V.cholerae (MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >2
Evidence 42 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

E.tarda

Source & Reference

dbAMP CAFPdb Antifungipept

Other

enic bacteria V.harveyi, V.parahaemolyticus, V.brasiliensis, V.cholerae (MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >200 ug/ml). Validated 7/202
Evidence 43 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

A.hydrophila

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lyticus, V.brasiliensis, V.cholerae (MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >200 ug/ml). Validated 7/2021 formatted 8/2024
Evidence 44 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

A.veronii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC >200 ug/ml), E.tarda (MIC >200 ug/ml), A.sobria, A.hydrophila (MIC >200 ug/ml), and A.veronii (MIC >200 ug/ml). Validated 7/2021 formatted 8/2024
Evidence 45 Activity

Activity

2.98% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
2.98% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis. | Dev Comp Immunol | 2019
Evidence 46 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2019 Mar 92:179-192.