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Peptide record

TPDB11602

Antibacterial Anticancer Antifungal Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB11602
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFGCPLNQGACHRHCRSIRRRGGYCSGIIKQTCTCY
Physicochemical Analysis
C165H265N59O46S6
DEMWV
CG
4003.65
9.27
8
0
8
+6
3.48
-0.444
46.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
83.80
15
Residue Composition
number
1
A
5
R
1
N
0
D
6
C
0
E
2
Q
6
G
2
H
3
I
1
L
1
K
0
M
1
F
1
P
2
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 0 C: 6 E: 0 Q: 2 G: 6 H: 2 I: 3 L: 1 K: 1 M: 0 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
36
C165H265N59O46S6
4003.65
9.27
+6
3.48
-0.444
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=50µM | Cytotoxicity: HEK293T: Not active up to 20 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Parasit Vectors. 2017 Oct 2 10(1):455.