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Peptide record

TPDB11602

Antibacterial Anticancer Antifungal Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB11602
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 36-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFGCPLNQGACHRHCRSIRRRGGYCSGIIKQTCTCY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C165H265N59O46S6
DEMWV
CG
4003.65
9.27
8
0
8
+6
2.27
-0.444
46.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
0.84
15
Residue Composition
number
1
A
5
R
1
N
0
D
6
C
0
E
2
Q
6
G
2
H
3
I
1
L
1
K
0
M
1
F
1
P
2
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 0 C: 6 E: 0 Q: 2 G: 6 H: 2 I: 3 L: 1 K: 1 M: 0 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
36 reviewed residue count
C165H265N59O46S6 sequence-only estimate (linear, free termini)
4003.65 sequence-only estimate (linear, free termini)
9.27 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.27 sequence-only estimate (linear, free termini)
-0.444 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis. | Parasit Vectors | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=50µM | Cytotoxicity: HEK293T: Not active up to 20 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Parasit Vectors. 2017 Oct 2 10(1):455.