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Peptide record

TPDB11596

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB11596
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia dbACP Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIEKVGQNIRDGIVKAGPAVAVVGQAATI
Physicochemical Analysis
C172H290N50O44
CHLMSY
AIKV
3762.50
11.08
7
2
17
+5
7.00
0.129
111.43
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
146.18
4
Residue Composition
number
5
A
2
R
1
N
1
D
0
C
1
E
2
Q
4
G
0
H
5
I
0
L
5
K
0
M
1
F
1
P
0
S
1
T
1
W
0
Y
5
V
Amino Acid Distribution
A: 5 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 5 L: 0 K: 5 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 5
Chemical Descriptors
35
C172H290N50O44
3762.50
11.08
+5
7.00
0.129
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12 µM

Target

Escherichia coli K12D31

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ion:bacteria:Escherichia coli (with one additional P at the N-terminus) is active against E. coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

i (with one additional P at the N-terminus) is active against E. coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22 uM), and G. saubinetii ( Li
Evidence 3 Activity

Activity

MIC
Antibacterial
22 µM

Target

P. chrysogenum

Source & Reference

dbAMP DRAMP

Other

coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22 uM), and G. saubinetii ( Li et al., 2007 ). Tandem repeat expression has reached the high yie
Evidence 4 Activity

Activity

MIC
Antibacterial
18 µM

Target

P. chrysogenum

Source & Reference

dbAMP DRAMP

Other

n the soluble form) ( Zhou et al., 2009 ). Active against Salmonella spp. (MIC 14 uM) and P. chrysogenum (MIC 18 uM). The recombinant form cleaved using hydroxylamine hydrochloride (with one additional Gly
Evidence 5 Activity

Activity

MIC
Antifungal
12 µM

Target

Escherichia coli K12D31

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ion:bacteria:Escherichia coli (with one additional P at the N-terminus) is active against E. coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22
Evidence 6 Activity

Activity

MIC
Antifungal
20 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

i (with one additional P at the N-terminus) is active against E. coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22 uM), and G. saubinetii ( Li
Evidence 7 Activity

Activity

MIC
Antifungal
22 µM

Target

P. chrysogenum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22 uM), and G. saubinetii ( Li et al., 2007 ). Tandem repeat expression has reached the high yie
Evidence 8 Activity

Activity

MIC
Antifungal
18 µM

Target

P. chrysogenum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

n the soluble form) ( Zhou et al., 2009 ). Active against Salmonella spp. (MIC 14 uM) and P. chrysogenum (MIC 18 uM). The recombinant form cleaved using hydroxylamine hydrochloride (with one additional Gly
Evidence 9 Activity

Activity

MIC
Antiparasitic
12 µM

Target

Escherichia coli K12D31

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
ion:bacteria:Escherichia coli (with one additional P at the N-terminus) is active against E. coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22
Evidence 10 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

i (with one additional P at the N-terminus) is active against E. coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22 uM), and G. saubinetii ( Li
Evidence 11 Activity

Activity

MIC
Antiparasitic
22 µM

Target

P. chrysogenum

Source & Reference

DRAMP

Other

coli K12D31 (MIC 12 uM), P. aeruginosa (MIC 20 uM), Salmonella spp. (MIC 14-16 uM), fungi P. chrysogenum (MIC 22 uM), and G. saubinetii ( Li et al., 2007 ). Tandem repeat expression has reached the high yie
Evidence 12 Activity

Activity

MIC
Antiparasitic
18 µM

Target

P. chrysogenum

Source & Reference

DRAMP

Other

n the soluble form) ( Zhou et al., 2009 ). Active against Salmonella spp. (MIC 14 uM) and P. chrysogenum (MIC 18 uM). The recombinant form cleaved using hydroxylamine hydrochloride (with one additional Gly
Evidence 13 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
A cationic amphiphilic peptide ABP-CM4 exhibits selective cytotoxicity against leukemia cells. | Peptides | 2010
Evidence 14 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
A cationic amphiphilic peptide ABP-CM4 exhibits selective cytotoxicity against leukemia cells. | Peptides | 2010
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A cationic amphiphilic peptide ABP-CM4 exhibits selective cytotoxicity against leukemia cells. | Peptides | 2010