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Peptide record

TPDB11589

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB11589
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIEKMGRNIRDGIVKAGPAIEVLGSAKAI
Physicochemical Analysis
C177H302N52O44S1
CQHTY
IK
3894.73
11.14
9
3
16
+6
8.51
-0.134
106.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
141.22
2
Residue Composition
number
4
A
3
R
1
N
1
D
0
C
2
E
0
Q
4
G
0
H
6
I
1
L
6
K
1
M
1
F
1
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 6 L: 1 K: 6 M: 1 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
35
C177H302N52O44S1
3894.73
11.14
+6
8.51
-0.134
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Lethal concentration=LC: Active against P. fluorescens (LC 1.6 uM), X. campestris (LC 1.2 uM), C. iodinum (LC 0.85 uM), A. tumefaciens (LC 0.41 uM), A. aecalis (LC 0.49 uM), A. polymorph (LC 1.8 uM), E. coli KI2 (LC 0.38 uM), S. marcescens (LC 0.67 uM), M. luteus (LC 0.59 uM), B. ammoniagenes (LC 0.49 uM), L. plantarum (LC 0.62 uM), A. simplex (LC 0.46 uM), B. subtilis (LC 3.6 uM), and B. sphaericus (LC 4.4 uM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Lethal concentration=LC: Active against P. fluorescens (LC 1.6 uM), X. campestris (LC 1.2 uM), C. iodinum (LC 0.85 uM), A. tumefaciens (LC 0.41 uM), A. aecalis (LC 0.49 uM), A. polymorph (LC 1.8 uM), E. coli KI2 (LC 0.38 uM), S. marcescens (LC 0.67 uM), M. luteus (LC 0.59 uM), B. ammoniagenes (LC 0.49 uM), L. plantarum (LC 0.62 uM), A. simplex (LC 0.46 uM), B. subtilis (LC 3.6 uM), and B. sphaericus (LC 4.4 uM).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Lethal concentration=LC: Active against P. fluorescens (LC 1.6 uM), X. campestris (LC 1.2 uM), C. iodinum (LC 0.85 uM), A. tumefaciens (LC 0.41 uM), A. aecalis (LC 0.49 uM), A. polymorph (LC 1.8 uM), E. coli KI2 (LC 0.38 uM), S. marcescens (LC 0.67 uM), M. luteus (LC 0.59 uM), B. ammoniagenes (LC 0.49 uM), L. plantarum (LC 0.62 uM), A. simplex (LC 0.46 uM), B. subtilis (LC 3.6 uM), and B. sphaericus (LC 4.4 uM).
Evidence 4 Activity

Activity

2% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
2% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation. | ACS Infect Dis | 2019