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Peptide record

TPDB11586

CB Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB11586
CB
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AI4AVP CPPsite3.0 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL
Physicochemical Analysis
C176H301N51O42S1
DCQHSTY
K
3835.70
11.23
9
2
17
+7
7.71
-0.071
106.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
143.39
2
Residue Composition
number
5
A
2
R
2
N
0
D
0
C
2
E
0
Q
4
G
0
H
4
I
2
L
7
K
1
M
1
F
1
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 7 M: 1 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
35
C176H301N51O42S1
3835.70
11.23
+7
7.71
-0.071
Free
L
Linear
Free
Antibacterial
Synthetic
Evidence Records 7 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Gastric Cancer
Ags
Stomach

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>>250 µM
Hemolytic Cytotoxic
50% Hemolysis | >>250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-antimicrobial Peptides: Folding-Mediated Host Defense Antagonists | J Biol Chem | 2013
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>200 µM
Cytotoxic
50% Cell death | >200 | µM | target cell: Human lymphoblast cells RPMI-7666

Target

Human lymphoblast cells RPMI-7666

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 4 Activity

Activity

50% Cell death
Toxicity
>50 µM
Cytotoxic
50% Cell death | >50 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 5 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human fibroblasts WI-38

Target

Human fibroblasts WI-38

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 6 Activity

Activity

35% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
35% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 7 Activity

Activity

<1% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
<1% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms. | Sci Rep | 2018