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Peptide record

TPDB11583

Antibacterial Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB11583
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 35-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
NKGCAICSIGAACLVDGPIPDFEIAGATGLFGLWG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C154H238N38O45S3
RQHMY
G
3437.99
3.70
1
3
16
-2
-0.68
0.840
100.57
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5625
1.64
6
Residue Composition
number
5
A
0
R
1
N
2
D
3
C
1
E
0
Q
7
G
0
H
4
I
3
L
1
K
0
M
2
F
2
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 2 C: 3 E: 1 Q: 0 G: 7 H: 0 I: 4 L: 3 K: 1 M: 0 F: 2 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
35 reviewed residue count
C154H238N38O45S3 sequence-only estimate (linear, free termini)
3437.99 sequence-only estimate (linear, free termini)
3.70 sequence-only estimate (linear, free termini)
-2 sequence-only estimate (linear, free termini)
-0.68 sequence-only estimate (linear, free termini)
0.840 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19633086] MLC=16 µM against rabbit blood agar

Target

erythrocytes

Source & Reference

NA
DRAMP
J Bacteriol. 2009 Sep 191(18):5690-6.