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Peptide record

TPDB11566

Antibacterial Anticancer Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11566
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFP
Physicochemical Analysis
C196H322N68O36
ANDCEQHKMSTWYV
P
4207.15
13.40
11
0
7
+11
11.56
-1.414
55.71
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
11
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
0
K
0
M
2
F
16
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 11 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 0 M: 0 F: 2 P: 16 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
35
C196H322N68O36
4207.15
13.40
+11
11.56
-1.414
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Escherichia coli ATCC 25922 or ML-35

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against parasite C. parvum in the form sporozoite but not oocyst. Active against E. coli ATCC 25922 or ML-35 (MIC 0.5 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 u
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP

Other

form sporozoite but not oocyst. Active against E. coli ATCC 25922 or ML-35 (MIC 0.5 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 uM), K. pneumoniae 13 clinical strains (MIC 0.25-1 uM), A.
Evidence 3 Activity

Activity

MIC
Antibacterial
1 µM

Target

S. marcescens ATCC8100

Source & Reference

dbAMP

Other

TCC 25922 or ML-35 (MIC 0.5 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 uM), K. pneumoniae 13 clinical strains (MIC 0.25-1 uM), A. baumannii (12 clinical strains (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
0.25-1 µM

Target

Klebsiella pneumoniae 13 clinical strains

Source & Reference

dbAMP

Other

enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 uM), K. pneumoniae 13 clinical strains (MIC 0.25-1 uM), A. baumannii (12 clinical strains (MIC 0.5-16 uM), P. aeruginosa 20 clinical strains (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
0.5-32 µM

Target

Pseudomonas aeruginosa 20 clinical strains

Source & Reference

dbAMP

Other

e 13 clinical strains (MIC 0.25-1 uM), A. baumannii (12 clinical strains (MIC 0.5-16 uM), P. aeruginosa 20 clinical strains (MIC 0.5-32 uM), B-cepacia 10 clinical strains (MIC > 64 uM), S.aureus ATCC 25923 (MIC >128 uM), fungi C.
Evidence 6 Activity

Activity

MIC
Antibacterial
>128 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

uginosa 20 clinical strains (MIC 0.5-32 uM), B-cepacia 10 clinical strains (MIC > 64 uM), S.aureus ATCC 25923 (MIC >128 uM), fungi C. neoformans (MIC 1-32 uM), P-etchellsii (MIC >32 uM), and C-albicans (MIC >64 uM
Evidence 7 Activity

Activity

MIC
Antibacterial
1-32 µM

Target

C. neoformans

Source & Reference

dbAMP

Other

M), B-cepacia 10 clinical strains (MIC > 64 uM), S.aureus ATCC 25923 (MIC >128 uM), fungi C. neoformans (MIC 1-32 uM), P-etchellsii (MIC >32 uM), and C-albicans (MIC >64 uM) ( Benincasa et al., 2004 ). It bi
Evidence 8 Activity

Activity

MIC
Antibacterial
16-32 µM

Target

Escherichia coli ATCC 25922 or ML-35

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 or ML-35 (MIC 16-32 uM), S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM),
Evidence 9 Activity

Activity

MIC
Antibacterial
>64 µM

Target

r. Typhimurium ATCC 14028

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 or ML-35 (MIC 16-32 uM), S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM), S.aureus ATCC 25923 (MIC >128 uM).
Evidence 10 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. marcescens ATCC8100

Source & Reference

dbAMP

Other

ATCC 25922 or ML-35 (MIC 16-32 uM), S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM), S.aureus ATCC 25923 (MIC >128 uM).
Evidence 11 Activity

Activity

MIC
Antibacterial
>128 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM), S.aureus ATCC 25923 (MIC >128 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
0.5 µM

Target

Escherichia coli ATCC 25922 or ML-35

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against parasite C. parvum in the form sporozoite but not oocyst. Active against E. coli ATCC 25922 or ML-35 (MIC 0.5 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 u
Evidence 13 Activity

Activity

MIC
Antifungal
0.5 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

form sporozoite but not oocyst. Active against E. coli ATCC 25922 or ML-35 (MIC 0.5 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 uM), K. pneumoniae 13 clinical strains (MIC 0.25-1 uM), A.
Evidence 14 Activity

Activity

MIC
Antifungal
1 µM

Target

S. marcescens ATCC8100

Source & Reference

dbAMP CAFPdb Antifungipept

Other

TCC 25922 or ML-35 (MIC 0.5 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 uM), K. pneumoniae 13 clinical strains (MIC 0.25-1 uM), A. baumannii (12 clinical strains (MI
Evidence 15 Activity

Activity

MIC
Antifungal
0.25-1 µM

Target

Klebsiella pneumoniae 13 clinical strains

Source & Reference

dbAMP CAFPdb Antifungipept

Other

enterica serovar Typhimurium ATCC 14028 (MIC 0.5 uM), S. marcescens ATCC8100 (MIC 1 uM), K. pneumoniae 13 clinical strains (MIC 0.25-1 uM), A. baumannii (12 clinical strains (MIC 0.5-16 uM), P. aeruginosa 20 clinical strains (MI
Evidence 16 Activity

Activity

MIC
Antifungal
0.5-32 µM

Target

Pseudomonas aeruginosa 20 clinical strains

Source & Reference

dbAMP CAFPdb Antifungipept

Other

e 13 clinical strains (MIC 0.25-1 uM), A. baumannii (12 clinical strains (MIC 0.5-16 uM), P. aeruginosa 20 clinical strains (MIC 0.5-32 uM), B-cepacia 10 clinical strains (MIC > 64 uM), S.aureus ATCC 25923 (MIC >128 uM), fungi C.
Evidence 17 Activity

Activity

MIC
Antifungal
>128 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uginosa 20 clinical strains (MIC 0.5-32 uM), B-cepacia 10 clinical strains (MIC > 64 uM), S.aureus ATCC 25923 (MIC >128 uM), fungi C. neoformans (MIC 1-32 uM), P-etchellsii (MIC >32 uM), and C-albicans (MIC >64 uM
Evidence 18 Activity

Activity

MIC
Antifungal
1-32 µM

Target

C. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), B-cepacia 10 clinical strains (MIC > 64 uM), S.aureus ATCC 25923 (MIC >128 uM), fungi C. neoformans (MIC 1-32 uM), P-etchellsii (MIC >32 uM), and C-albicans (MIC >64 uM) ( Benincasa et al., 2004 ). It bi
Evidence 19 Activity

Activity

MIC
Antifungal
16-32 µM

Target

Escherichia coli ATCC 25922 or ML-35

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against E. coli ATCC 25922 or ML-35 (MIC 16-32 uM), S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM),
Evidence 20 Activity

Activity

MIC
Antifungal
>64 µM

Target

r. Typhimurium ATCC 14028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against E. coli ATCC 25922 or ML-35 (MIC 16-32 uM), S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM), S.aureus ATCC 25923 (MIC >128 uM).
Evidence 21 Activity

Activity

MIC
Antifungal
32 µM

Target

S. marcescens ATCC8100

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ATCC 25922 or ML-35 (MIC 16-32 uM), S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM), S.aureus ATCC 25923 (MIC >128 uM).
Evidence 22 Activity

Activity

MIC
Antifungal
>128 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S-enterica Ser. Typhimurium ATCC 14028 (MIC >64 uM), S. marcescens ATCC8100 (MIC 32 uM), S.aureus ATCC 25923 (MIC >128 uM).
Evidence 23 Activity

Activity

0% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
0% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 24 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 25 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 26 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Oct 6 21(19):7367.