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Peptide record

TPDB11565

Antibacterial Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB11565
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 35-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RGLRRLGRKIAHGVKKYGPTVLRIIRIAGGGGGSC
Physicochemical Analysis
C160H282N58O39S1
NDEQMFW
G
3674.42
12.41
10
0
12
+9
5.30
-0.171
100.29
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
40.55
4
Residue Composition
number
2
A
6
R
0
N
0
D
1
C
0
E
0
Q
9
G
1
H
4
I
3
L
3
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 9 H: 1 I: 4 L: 3 K: 3 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
35
C160H282N58O39S1
3674.42
12.41
+9
5.30
-0.171
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
146 µM
Hemolytic Cytotoxic
50% Hemolysis | 146 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 2 Activity

Activity

50% Cell death
Toxicity
2.14 µM
Cytotoxic
50% Cell death | 2.14 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011