Back to search

Peptide record

TPDB11556

LFchimera Antibacterial Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11556
LFchimera
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
FKCRRWQWRMKKLGKRSKNKGFKEQAKSLLKWILD
Physicochemical Analysis
C203H330N62O45S2
HPTYV
K
4423.36
11.65
13
2
12
+11
6.26
-1.263
58.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
16500
373.02
6
Residue Composition
number
1
A
4
R
1
N
1
D
1
C
1
E
2
Q
2
G
0
H
1
I
4
L
9
K
1
M
2
F
0
P
2
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 1 C: 1 E: 1 Q: 2 G: 2 H: 0 I: 1 L: 4 K: 9 M: 1 F: 2 P: 0 S: 2 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
35
C203H330N62O45S2
4423.36
11.65
+11
6.26
-1.263
Free
L
Cationic
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Enteroaggregative Escherichia Coli (Eaec)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
Cytoplasm
After 30 min of incubation LFcin17-30, LFampin265-284 and LFchimera can be found in the EAEC cytoplasm, and only a low proportion of the peptides were visualized on the membrane. LFchimera is more efficient at disrupting the integrity of the cell membrane than others
Membrane distruption
In vitro
CCHHHHHHHHHHHHCCCCCC
Additional Detail Fields 1 fields
CCHHHHHHHHHHHHCCCCCC