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Peptide record

TPDB11555

Antibacterial Anticancer Antifungal Toxicity standard

35 amino acids

3D PDB MODEL

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TPDB ID TPDB11555

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 35-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLR

FASTA

>TPDB11555|Antibacterial;Anticancer;Antifungal;Toxicity|length=35
SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLR

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

Formula C160H283N63O42

Absent Amino Acids NDCEIMWY

Common Amino Acids R

Mass 3761.40

PI 13.18

Basic Residues 12

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +11

Boman Index 3.24

Hydrophobicity -0.909

Aliphatic Index 61.43

N-end Rule Half-life Estimate

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 6

number

Amino Acid Distribution

A: 4 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 6 H: 1 I: 0 L: 3 K: 4 M: 0 F: 1 P: 1 S: 3 T: 2 W: 0 Y: 0 V: 2

Length

35 reviewed residue count

Formula

C160H283N63O42 sequence-only estimate (linear, free termini)

Mass

3761.40 sequence-only estimate (linear, free termini)

13.18 sequence-only estimate (linear, free termini)

Net Charge

+11 sequence-only estimate (linear, free termini)

Boman Index

3.24 sequence-only estimate (linear, free termini)

Hydrophobicity

-0.909 sequence-only estimate (linear, free termini)

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.3 µM

Target

Target Organism Escherichia coli ML35p

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), and C. albicans 820 (MI

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.0 µM

Target

Target Organism L. monocytogenes EGD

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), and C. albicans 820 (MIC 0.9 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.9 µM

Target

Target Organism Candida albicans 820

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), and C. albicans 820 (MIC 0.9 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.3 µM

Target

Target Organism Escherichia coli ML35p

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), and C. albicans 820 (MI

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.0 µM

Target

Target Organism L. monocytogenes EGD

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), and C. albicans 820 (MIC 0.9 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.9 µM

Target

Target Organism Candida albicans 820

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), and C. albicans 820 (MIC 0.9 uM).

Evidence 7 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1-40 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 1-40 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii. | Acta Naturae | 2014